7-Methoxy-5-(4-methyl-3-nitro-phenyl)-1,3,4,5-tetrahydro-indeno[1,2-b]pyridin-2-one

Base Information

• Chemical Name: 7-Methoxy-5-(4-methyl-3-nitro-phenyl)-1,3,4,5-tetrahydro-indeno[1,2-b]pyridin-2-one
• CAS No.: 88687-21-2
• Molecular Formula: C₂₀H₁₈N₂O₄
• Molecular Weight: 350.374
• Mol file: 88687-21-2.mol

Synonyms:7-Methoxy-5-(4-methyl-3-nitro-phenyl)-1,3,4,5-tetrahydro-indeno[1,2-b]pyridin-2-one

Chemical Property of 7-Methoxy-5-(4-methyl-3-nitro-phenyl)-1,3,4,5-tetrahydro-indeno[1,2-b]pyridin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Methoxy-5-(4-methyl-3-nitro-phenyl)-1,3,4,5-tetrahydro-indeno[1,2-b]pyridin-2-one

There total 1 articles about 7-Methoxy-5-(4-methyl-3-nitro-phenyl)-1,3,4,5-tetrahydro-indeno[1,2-b]pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-3-nitrobenzaldehyde (31680-07-6) + 5-(4-methoxyphenyl)-5-oxopentanenitrile (26823-02-9) → 7-Methoxy-5-(4-methyl-3-nitro-phenyl)-1,3,4,5-tetrahydro-indeno[1,2-b]pyridin-2-one (88687-21-2)

Guidance literature:

Yield given. Multistep reaction; 2.) polyphosphoric acid, 4 h;

DOI:10.1021/jm00370a004

Reference yield: 68.0%

7-Methoxy-5-(4-methyl-3-nitro-phenyl)-1,3,4,5-tetrahydro-indeno[1,2-b]pyridin-2-one (88687-21-2) → (4aS,5S,9bS)-5-(3-Amino-4-methyl-phenyl)-7-methoxy-1,3,4,4a,5,9b-hexahydro-indeno[1,2-b]pyridin-2-one (88687-27-8)

Guidance literature:

With hydrogen; nickel; In ethanol; at 80 ℃; for 15h; under 76000.1 Torr;

DOI:10.1021/jm00370a004

Reference yield:

7-Methoxy-5-(4-methyl-3-nitro-phenyl)-1,3,4,5-tetrahydro-indeno[1,2-b]pyridin-2-one (88687-21-2) → (4aS,5S,9bS)-5-(3-Amino-4-methyl-phenyl)-2,3,4,4a,5,9b-hexahydro-1H-indeno[1,2-b]pyridin-7-ol (88763-27-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / H₂ / Raney nickel / ethanol / 15 h / 80 °C / 76000.1 Torr

2: 88 percent / LAH

3: pyridinium chloride

With lithium aluminium tetrahydride; hydrogen; pyridine hydrochloride; nickel; In ethanol;

DOI:10.1021/jm00370a004

upstream raw materials:

4-methyl-3-nitrobenzaldehyde

5-(4-methoxyphenyl)-5-oxopentanenitrile

Downstream raw materials:

(4aS,5S,9bS)-5-(3-Amino-4-methyl-phenyl)-7-methoxy-1,3,4,4a,5,9b-hexahydro-indeno[1,2-b]pyridin-2-one

(4aS,5S,9bS)-5-(3-Amino-4-methyl-phenyl)-2,3,4,4a,5,9b-hexahydro-1H-indeno[1,2-b]pyridin-7-ol