N-(4-{1-[2-(2,4,6-trimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

Base Information

Chemical Name:N-(4-{1-[2-(2,4,6-trimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide
CAS No.:1076690-56-6
Molecular Formula:C₂₁H₂₅N₃O₃S
Molecular Weight:399.514
Hs Code.:

Synonyms:N-(4-{1-[2-(2,4,6-trimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-{1-[2-(2,4,6-trimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4-{1-[2-(2,4,6-trimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

There total 5 articles about N-(4-{1-[2-(2,4,6-trimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1076690-88-4
N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate

: 4408-60-0
2-mesitylacetic acid

: 1076690-56-6
N-(4-{1-[2-(2,4,6-trimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

Guidance literature:: 2-mesitylacetic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 1.5h;

N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate; With caesium carbonate; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1076690-81-7
3-(4-nitro-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester

: 1076690-56-6
N-(4-{1-[2-(2,4,6-trimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1.25 h / 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1.5 h / 20 °C

4.2: 2 h / 20 °C

With oxalyl dichloride; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1076690-82-8
3-(4-amino-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester

: 1076690-56-6
N-(4-{1-[2-(2,4,6-trimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1.25 h / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1.5 h / 20 °C

3.2: 2 h / 20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;