N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate

Base Information

• Chemical Name: N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate
• CAS No.: 1076690-88-4
• Molecular Formula: C₂HF₃O₂*C₁₀H₁₃N₃O₂S
• Molecular Weight: 353.322
• Mol file: 1076690-88-4.mol

Synonyms:N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate

Chemical Property of N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate

There total 4 articles about N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-(4-methanesulfonylamino-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester (1076690-86-2) → N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate (1076690-88-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.25h;

Reference yield:

3-(4-nitro-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester (1076690-81-7) → N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate (1076690-88-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 1.25 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

3-(4-nitro-phenyl)-4,5-dihydro-1H-pyrazole (103753-04-4) → N-[4-(4,5-dihydro-1H-pyrazol-3-yl)-phenyl]-methanesulfonamide trifluoroacetate (1076690-88-4)

Guidance literature:

Multi-step reaction with 4 steps

1: dmap / tetrahydrofuran / 2 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.67 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 1.25 h / 20 °C

With dmap; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

3-(4-methanesulfonylamino-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester

3-(4-amino-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester

3-(4-nitro-phenyl)-4,5-dihydro-pyrazole-1-carboxylic acid tert-butyl ester

3-(4-nitro-phenyl)-4,5-dihydro-1H-pyrazole

Downstream raw materials:

N-(4-{1-[2-(2,4-dimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

N-(4-{1-[2-(2,4,6-trimethyl-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

N-(4-{1-[2-(2-bromo-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide

N-(4-{1-[2-(2-chloro-4,5-dimethoxy-phenyl)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-phenyl)-methanesulfonamide