3-(2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-hydroxyethyl)phenol

Base Information

Chemical Name:3-(2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-hydroxyethyl)phenol
CAS No.:1360460-65-6
Molecular Formula:C₃₀H₃₃NO₃
Molecular Weight:455.597
Hs Code.:

Synonyms:3-(2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-hydroxyethyl)phenol

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Chemical Property of 3-(2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-hydroxyethyl)phenol

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Technology Process of 3-(2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-hydroxyethyl)phenol

There total 4 articles about 3-(2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-hydroxyethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1360460-68-9
1-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-2-hydroxy-2-(3-hydroxyphenyl)ethanone

: 1360460-65-6
3-(2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-hydroxyethyl)phenol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.12.008

Reference yield:

: 1210-33-9
5-chlorodibenzosuberane

: 1360460-65-6
3-(2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-hydroxyethyl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 20 °C

2: potassium permanganate; potassium hydroxide / pyridine; water / 5 h / 20 °C / Cooling with ice

3: O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With potassium permanganate; lithium aluminium tetrahydride; O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate; triethylamine; potassium hydroxide; In tetrahydrofuran; pyridine; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.12.008

Reference yield:

: 47337-71-3
3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octane

: 1360460-65-6
3-(2-(3α-((10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy)-8-azabicyclo[3.2.1]octan-8-yl)-1-hydroxyethyl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.12.008