4-chloro-N-[5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-phenyl]butyramide

Base Information

Chemical Name:4-chloro-N-[5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-phenyl]butyramide
CAS No.:865305-40-4
Molecular Formula:C₁₈H₂₄ClN₅O₃
Molecular Weight:393.873
Hs Code.:

Synonyms:4-chloro-N-[5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-phenyl]butyramide

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Chemical Property of 4-chloro-N-[5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-phenyl]butyramide

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Technology Process of 4-chloro-N-[5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-phenyl]butyramide

There total 8 articles about 4-chloro-N-[5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-phenyl]butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 865305-33-5
5-(5-amino-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine

: 4635-59-0
4-Chlorobutanoyl chloride

: 865305-40-4
4-chloro-N-[5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-phenyl]butyramide

Guidance literature:: With disodium hydrogenphosphate; In chloroform; for 4.5h;

Reference yield:

: 865305-34-6
toluene-4-sulfonic acid 2-isopropyl-4-methoxy-phenyl ester

: 865305-40-4
4-chloro-N-[5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-phenyl]butyramide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; nitric acid / 16.33 h

1.2: 0.75 h / 100 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

3.1: tert-Butoxybis(dimethylamino)methane / ethanol / 0.75 h / 100 °C

3.2: 20 h / Reflux

3.3: 5 h / 130 °C

4.1: palladium 10% on activated carbon; hydrogen / ethanol / 1810.07 Torr

5.1: disodium hydrogenphosphate / dichloromethane; water; chloroform / 4.5 h

With disodium hydrogenphosphate; tert-Butoxybis(dimethylamino)methane; palladium 10% on activated carbon; hydrogen; nitric acid; potassium carbonate; acetic acid; In ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 865305-39-1
(2-isopropyl-4-methoxy-5-nitro-phenoxy)-acetonitrile

: 865305-40-4
4-chloro-N-[5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-phenyl]butyramide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert-Butoxybis(dimethylamino)methane / ethanol / 0.75 h / 100 °C

1.2: 20 h / Reflux

1.3: 5 h / 130 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 1810.07 Torr

3.1: disodium hydrogenphosphate / dichloromethane; water; chloroform / 4.5 h

With disodium hydrogenphosphate; tert-Butoxybis(dimethylamino)methane; palladium 10% on activated carbon; hydrogen; In ethanol; dichloromethane; chloroform; water;