4635-59-0

Basic information

• Product Name: 4-Chlorobutyryl chloride
• Synonyms: 4-chloro-butanoylchlorid;4-Chlorobutyl chloride;4-chloro-butyrylchlorid;-Chlorobutyrylchloride;gamma-chlorobutyroylchloride;gamma-Chlorobutyryl chloride;gamma-chlorobutyrylchloride;gamma-Chloro-n-butyryl chloride
• CAS NO: 4635-59-0
• Molecular Formula: C₄H₆Cl₂O
• Molecular Weight: 141
• EINECS: 225-059-1
• Product Categories: ACID CHLORIDES;Acid Halides;Carbonyl Compounds;Organic Building Blocks;Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 4635-59-0.mol
• Article Data: 35

Chemical Properties

• Melting Point: -47 °C
• Boiling Point: 173-174 °C(lit.)
• Flash Point: 163 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.26 g/mL at 25 °C(lit.)
• Vapor Pressure: 3 mm Hg ( 20 °C)
• Refractive Index: n20/D 1.461(lit.)
• Storage Temp.: Store below +30°C.
• Explosive Limit: 5.5-11.7%(V)
• Water Solubility: soluble in diethyl ether, ethanol, slightly soluble in water.
• Sensitive: Moisture Sensitive
• BRN: 773860
• CAS DataBase Reference: 4-Chlorobutyryl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chlorobutyryl chloride(4635-59-0)
• EPA Substance Registry System: 4-Chlorobutyryl chloride(4635-59-0)

Safety Data

• Hazard Codes: T,C
• Statements: 22-23-35
• Safety Statements: 26-28-36/37/39-45-28A
• RIDADR: UN 3390 6.1/PG 1
• WGK Germany: 1
• RTECS: EM1406000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 4635-59-0(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to yellow liquid

Uses

Different sources of media describe the Uses of 4635-59-0 differently. You can refer to the following data:
1. 4-Chlorobutyroyl Chloride is used in the preparation of mitosene and mitosane analogs of Mitomycin C (M371900), an antitumor antibiotic. .
2. 4-Chlorobutyryl chloride (4-CBCl) is mainly used in the production of pharmaceuticals and agrochemicals. It is used as pyrazinamide intermediate.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C4H6Cl2O/c5-3-1-2-4(6)7/h1-3H2

Upstream product

• 141-75-3 butyryl chloride 
• 107-92-6 butyric acid 
• 96-48-0 4-butanolide 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 56-23-5 tetrachloromethane 
• 7791-25-5 sulfuryl dichloride 
• 94-36-0 dibenzoyl peroxide 
• 201230-82-2 carbon monoxide 
• 75-19-4 cyclopropane 
• 71-43-2 benzene 
• 55133-95-4 C₁₀H₂₄O₃Si₂ 
• 627-00-9 γ-chlorobutyric acid 
• 98-07-7 Benzotrichlorid 
• 4885-02-3 Dichloromethyl methyl ether 

Downstream Products

• 69966-83-2 4-chloro-1-(morpholin-4-yl)butan-1-one 
• 191168-66-8 N-(p-tolyl)-4-chlorobutyramide 
• 22813-58-7 N,N-dimethyl-4-chlorobutyramide 
• 56794-28-6 4-chloro-N,N-diethylbutyramide 
• 7578-45-2 N-phenyl-4-chlorobutyramide 
• 75343-44-1 cyclopropyl (4-ethoxyphenyl)-methanone 
• 22813-61-2 N-benzyl-4-chlorobutanamide 
• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 
• 29882-07-3 4-chlorobutanal dimethyl acetal 
• 500730-11-0 4-chloro-butyric acid-(2-nitro-benzylamide) 
• 939-52-6 4-chloro-1-phenylbutan-1-one 
• 6139-84-0 4-chlorobutyraldehyde 
• 3481-02-5 cyclopropyl phenyl ketone 
• 81093-55-2 2-(4-Chlorbutyrylamino)-benzthiazol 

Relevant articles and documents

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Intramolecular Cyclization of Brominated Oxime Ether Promoted with Ytterbium(0) to the Synthesis of Cyclic Imines

The first utility of ytterbium(0) as a mediating-metal in the intramolecular cyclization of brominated oxime ether was reported in this paper. In contrast to the prior methods, the N–O bond was used as a receptor of nucleophilic reagent, rather than as a source of N-centered radicals. Cyclic imines were obtained in this one-pot reaction with a broad scope of substrates and feasible reaction conditions.

FGFR INHIBITOR AND APPLICATION THEREOF

An azatricyclic compound (as represented by formula I) which acts as an inhibitor of fibroblast growth factor receptors (FGFR), as well as a pharmaceutical composition thereof, a preparation method, and a use therefor in the treatment of FGFR-mediated diseases. The azatricyclic compound exerts an effect by means of participating in the regulation of a plurality of processes such as cell proliferation, apoptosis, migration, neovascularization, and the like. AA%%%Formula (I).