13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl o-tolylcarbamate

Base Information

Chemical Name:13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl o-tolylcarbamate
CAS No.:1393714-24-3
Molecular Formula:C₂₅H₂₅N₃O₂
Molecular Weight:399.492
Hs Code.:

Synonyms:13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl o-tolylcarbamate

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Chemical Property of 13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl o-tolylcarbamate

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Technology Process of 13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl o-tolylcarbamate

There total 7 articles about 13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl o-tolylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1393714-15-2
6,8,13,13a-tetrahydro-13-methyl-5H-isoquinolino[1,2-b]quinazolin-10-ol

: 614-68-6
2-tolyl isocyanate

: 1393714-24-3
13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl o-tolylcarbamate

Guidance literature:: 6,8,13,13a-tetrahydro-13-methyl-5H-isoquinolino[1,2-b]quinazolin-10-ol; With triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

2-tolyl isocyanate; In dichloromethane; at 20 ℃;
DOI:10.1021/ml3001825

Reference yield:

: 1393714-33-4
10-hydroxy-13-methyl-13,13a-dihydro-5H-isoquinolino[1,2-b]quinazolin-8(6H)-one

: 1393714-24-3
13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl o-tolylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 70 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.25 h / 20 °C

2.2: 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ml3001825

Reference yield:

: 3230-65-7
3,4-dihydroisoquinoline

: 1393714-24-3
13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl o-tolylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 24 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 70 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0.25 h / 20 °C

3.2: 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ml3001825