3,4-Dihydroisoquinoline

Base Information

Chemical Name:3,4-Dihydroisoquinoline
CAS No.:3230-65-7
Molecular Formula:C9H9N
Molecular Weight:131.177
Hs Code.:
European Community (EC) Number:221-769-0
NSC Number:3007
UNII:2K2ZCG3PSZ
DSSTox Substance ID:DTXSID20186037
Nikkaji Number:J262.336F
Wikidata:Q72465363
Mol file:3230-65-7.mol

Synonyms:3,4-dihydroisoquinoline;G 1616

Suppliers and Price of 3,4-Dihydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,4-Dihydroisoquinoline
5g
$ 1540.00

Sigma-Aldrich
3,4-Dihydroisoquinoline ≥97.5% (GC)
1g
$ 164.00

Sigma-Aldrich
3,4-Dihydroisoquinoline ≥97.5% (GC)
5g
$ 626.00

Matrix Scientific
3,4-Dihydroisoquinoline 95%
25g
$ 2146.00

Labseeker
3,4-Dihydroisoquinoline 95
1g
$ 750.00

Crysdot
3,4-Dihydroisoquinoline 95+%
1g
$ 196.00

Chemenu
3,4-Dihydroisoquinoline 95%
5g
$ 494.00

American Custom Chemicals Corporation
3,4-DIHYDROISOQUINOLINE 95.00%
5MG
$ 499.52

Ambeed
3,4-Dihydroisoquinoline 96%
1g
$ 102.00

Ambeed
3,4-Dihydroisoquinoline 96%
250mg
$ 41.00

Total 34 raw suppliers

Chemical Property of 3,4-Dihydroisoquinoline

Chemical Property:

Vapor Pressure:0.0548mmHg at 25°C
Melting Point:251-254℃
Refractive Index:1.6041 (589.3 nm 30℃)
Boiling Point:241.8 °C at 760 mmHg
PKA:5.80±0.20(Predicted)
Flash Point:91.6 °C
PSA：12.36000
Density:1.05 g/cm³
LogP:1.09720
Storage Temp.:2-8°C
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:131.073499291
Heavy Atom Count:10
Complexity:140

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dihydroisoquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 22-24-36/38
Safety Statements: 26-36/37-45

MSDS Files:

Useful:

Canonical SMILES:C1CN=CC2=CC=CC=C21
Uses 3,4-Dihydroisoquinoline is derived from 1,2,3,4-Tetrahydroisoquinoline (T293820), which is used as a reagent in the preparation of 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides as antiproliferative tubulin inhibitors. 3,4-Dihydroisoquinoline can be used as a reactant to synthesize: 5,6-Dihydro-8H-isoquino[1,2-b]quinazolin-8-one by decarboxylative cyclization reaction with isatoic anhydride using tetrabutylammonium iodide (TBAI). 1-naphtholyl tetrahydroisoquinoline by aza-Friedel-Crafts reaction with various naphthols. 3,4-dihydroisoquinoline pseudo bases, which are employed as starting materials for the preperation of 3-benzazepine derivatives.

Technology Process of 3,4-Dihydroisoquinoline

There total 86 articles about 3,4-Dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 23069-99-0
N-(2-phenylethyl)formamide

: 3230-65-7
3,4-dihydroisoquinoline

Guidance literature:: With PPA; at 200 - 220 ℃; for 1h;
DOI:10.1002/jhet.5570420426

Reference yield: 91.0%

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 3230-65-7
3,4-dihydroisoquinoline

: (3,4-dihydroisoquinolin-2(1H)-yl)(3-(trifluoromethyl)phenyl)methanone

Guidance literature:: With safranin O; In tetrahydrofuran; at 20 ℃; for 20h; Sealed tube; Irradiation; Green chemistry;
DOI:10.1021/ol5029354

Reference yield: 91.0%

: 2744-08-3,2744-09-4,6329-61-9
decahydroisoquinoline

: 3230-65-7
3,4-dihydroisoquinoline

Guidance literature:: decahydroisoquinoline; With N-Bromosuccinimide; In dichloromethane; at 20 ℃; for 1h;

With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 3h;
DOI:10.1021/jo502842s