morpholin-4-yl[3-(phenylsulfonyl)-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl]methanone

Base Information

Chemical Name:morpholin-4-yl[3-(phenylsulfonyl)-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl]methanone
CAS No.:1350457-86-1
Molecular Formula:C₂₃H₂₈N₄O₄S
Molecular Weight:456.566
Hs Code.:

Synonyms:morpholin-4-yl[3-(phenylsulfonyl)-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl]methanone

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Chemical Property of morpholin-4-yl[3-(phenylsulfonyl)-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl]methanone

Chemical Property:

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Technology Process of morpholin-4-yl[3-(phenylsulfonyl)-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl]methanone

There total 11 articles about morpholin-4-yl[3-(phenylsulfonyl)-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350457-80-5
1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl(morpholin-4-yl)methanone

: 98-09-9
benzenesulfonyl chloride

: 1350457-86-1
morpholin-4-yl[3-(phenylsulfonyl)-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl]methanone

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 129799-08-2
tert-butyl methyl piperazine-1,3-dicarboxylate

: 1350457-86-1
morpholin-4-yl[3-(phenylsulfonyl)-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl]methanone

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 36 h / Reflux

2.1: water; ammonium chloride; iron / methanol / 1 h / Reflux

3.1: hypophosphorous acid; sodium nitrite / copper(I) oxide / water / 2 h / 0 °C

3.2: pH 8

4.1: hydrogen; ammonia / Raney_.(R).-nickel / methanol / 48 h / 20 °C / 2068.65 Torr

5.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

6.1: potassium carbonate / acetonitrile / 20 °C / Reflux

7.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

7.2: -78 °C / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

9.1: hydrogen / 20% palladium hydroxide-activated charcoal / ethanol / 1 h / 50 °C / 1551.49 Torr

10.1: triethylamine / dichloromethane / 1 h / 20 °C

With lithium aluminium tetrahydride; ammonia; water; hydrogen; hypophosphorous acid; iron; potassium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; copper(I) oxide; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 17417-09-3
2-fluoro-5-nitrobenzonitrile

: 1350457-86-1
morpholin-4-yl[3-(phenylsulfonyl)-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl]methanone

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 36 h / Reflux

2.1: water; ammonium chloride; iron / methanol / 1 h / Reflux

3.1: hypophosphorous acid; sodium nitrite / copper(I) oxide / water / 2 h / 0 °C

3.2: pH 8

4.1: hydrogen; ammonia / Raney_.(R).-nickel / methanol / 48 h / 20 °C / 2068.65 Torr

5.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

6.1: potassium carbonate / acetonitrile / 20 °C / Reflux

7.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

7.2: -78 °C / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

9.1: hydrogen / 20% palladium hydroxide-activated charcoal / ethanol / 1 h / 50 °C / 1551.49 Torr

10.1: triethylamine / dichloromethane / 1 h / 20 °C

With lithium aluminium tetrahydride; ammonia; water; hydrogen; hypophosphorous acid; iron; potassium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; copper(I) oxide; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;