2-(Dimethylamino)-2-oxoethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate

Base Information

Chemical Name:2-(Dimethylamino)-2-oxoethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate
CAS No.:1415043-81-0
Molecular Formula:C₂₇H₂₈FN₃O₆S
Molecular Weight:541.6
Hs Code.:

Synonyms:2-(Dimethylamino)-2-oxoethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate

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Chemical Property of 2-(Dimethylamino)-2-oxoethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate

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Technology Process of 2-(Dimethylamino)-2-oxoethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate

There total 7 articles about 2-(Dimethylamino)-2-oxoethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1415043-08-1
(3-{2-[(4-Fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetic acid

: 2675-89-0
2-chloro-N,N-dimethylacetamide

: 1415043-81-0
2-(Dimethylamino)-2-oxoethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 96h;

Reference yield:

: 845267-78-9
tert-butyl 2,4-dioxopiperidine-1-carboxylate

: 1415043-81-0
2-(Dimethylamino)-2-oxoethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / chloroform / 20 °C

2: sodium acetate / ethanol / 20 °C

3: acetic anhydride; hypophosphorous acid; water; hydrogen iodide / 96 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 96 h / 20 °C

With water; hydrogen iodide; sodium acetate; hypophosphorous acid; acetic anhydride; potassium carbonate; In ethanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 643763-14-8
2-[(4-fluorophenyl)sulfanyl]benzaldehyde

: 1415043-81-0
2-(Dimethylamino)-2-oxoethyl (3-{2-[(4-fluorophenyl)sulfonyl]benzyl}-2-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-1-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Cooling with acetone-dry ice

2: acetic anhydride; hypophosphorous acid; water; hydrogen iodide / 96 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 96 h / 20 °C

With water; hydrogen iodide; hypophosphorous acid; acetic anhydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;