(S)-2-({(4S,5R)-2-[2-(1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazol-4-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-3-methyl-pentanoic acid

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Chemical Name:(S)-2-({(4S,5R)-2-[2-(1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazol-4-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-3-methyl-pentanoic acid
CAS No.:101817-34-9
Molecular Formula:C₂₇H₃₆N₄O₆S
Molecular Weight:544.672
Hs Code.:

Synonyms:(S)-2-({(4S,5R)-2-[2-(1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazol-4-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-3-methyl-pentanoic acid

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Chemical Property of (S)-2-({(4S,5R)-2-[2-(1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazol-4-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-3-methyl-pentanoic acid

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Technology Process of (S)-2-({(4S,5R)-2-[2-(1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazol-4-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-3-methyl-pentanoic acid

There total 9 articles about (S)-2-({(4S,5R)-2-[2-(1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazol-4-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-3-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 101817-33-8
(S)-2-({(4S,5R)-2-[2-(1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazol-4-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-3-methyl-pentanoic acid methyl ester

: 101817-34-9
(S)-2-({(4S,5R)-2-[2-(1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazol-4-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-3-methyl-pentanoic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; for 5h; Ambient temperature;
DOI:10.1016/S0040-4039(00)98736-7

Reference yield:

: 101817-25-8
2-((S)-1-Hydroxy-2-phenyl-ethyl)-thiazole-4-carbonitrile

: 101817-34-9
(S)-2-({(4S,5R)-2-[2-(1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazol-4-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-3-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / NaOEt / 24 h / Ambient temperature

2: 85 percent / CH₂Cl₂ / 24 h / Ambient temperature

3: 80 percent / diethylazodicarboxylate, PPh₃, HN₃ / 1 h / Ambient temperature

4: 75 percent

5: 90 percent / NaOH / dioxane; H₂O / 5 h / Ambient temperature

With sodium hydroxide; tris-(2-chloro-ethyl)-amine; sodium ethanolate; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/S0040-4039(00)98736-7

Reference yield:

: 101817-24-7
2-((S)-1-Hydroxy-2-phenyl-ethyl)-thiazole-4-carboxylic acid amide

: 101817-34-9
(S)-2-({(4S,5R)-2-[2-(1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-thiazol-4-yl]-5-methyl-4,5-dihydro-oxazole-4-carbonyl}-amino)-3-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / TFAA, Py / 0.17 h / 0 °C

2: 84 percent / NaOEt / 24 h / Ambient temperature

3: 85 percent / CH₂Cl₂ / 24 h / Ambient temperature

4: 80 percent / diethylazodicarboxylate, PPh₃, HN₃ / 1 h / Ambient temperature

5: 75 percent

6: 90 percent / NaOH / dioxane; H₂O / 5 h / Ambient temperature

With pyridine; sodium hydroxide; tris-(2-chloro-ethyl)-amine; sodium ethanolate; triphenylphosphine; trifluoroacetic anhydride; diethylazodicarboxylate; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/S0040-4039(00)98736-7