tert-Butyl (3-exo)-3-[benzyl(methyl)amino]-8-azabicyclo[3.2.1]octane-8-carboxylate

Base Information

Chemical Name:tert-Butyl (3-exo)-3-[benzyl(methyl)amino]-8-azabicyclo[3.2.1]octane-8-carboxylate
CAS No.:1307254-46-1
Molecular Formula:C₂₀H₃₀N₂O₂
Molecular Weight:330.47
Hs Code.:

Synonyms:tert-Butyl (3-exo)-3-[benzyl(methyl)amino]-8-azabicyclo[3.2.1]octane-8-carboxylate

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Chemical Property of tert-Butyl (3-exo)-3-[benzyl(methyl)amino]-8-azabicyclo[3.2.1]octane-8-carboxylate

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Technology Process of tert-Butyl (3-exo)-3-[benzyl(methyl)amino]-8-azabicyclo[3.2.1]octane-8-carboxylate

There total 10 articles about tert-Butyl (3-exo)-3-[benzyl(methyl)amino]-8-azabicyclo[3.2.1]octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307254-45-0
tert-butyl (1R,3s,5S)-3-(methylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate

: 100-52-7
benzaldehyde

: 1307254-46-1
tert-Butyl (3-exo)-3-[benzyl(methyl)amino]-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: tert-butyl (1R,3s,5S)-3-(methylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate; benzaldehyde; With acetic acid; In methanol; for 1h;

With sodium tris(acetoxy)borohydride; In methanol; at 20 ℃; Cooling with ice;

Reference yield:

: 744183-20-8,174486-93-2
tert-butyl (1R,3s,5S)-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1307254-46-1
tert-Butyl (3-exo)-3-[benzyl(methyl)amino]-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / chloroform; water / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / water; methanol / 760.05 Torr

4.1: acetic acid / methanol / 1 h

4.2: 20 °C / Cooling with ice

With hydrogen; sodium hydride; sodium hydrogencarbonate; acetic acid; palladium 10% on activated carbon; In methanol; chloroform; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 185099-67-6
N-Boc-nortropinone

: 1307254-46-1
tert-Butyl (3-exo)-3-[benzyl(methyl)amino]-8-azabicyclo[3.2.1]octane-8-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: calcium chloride / methanol / 0.5 h / Cooling with ice

1.2: 1 h

2.1: triethylamine / dichloromethane / 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 55 °C

4.1: hydrogen / palladium 10% on activated carbon / water; methanol / 760.05 Torr

5.1: sodium hydrogencarbonate / chloroform; water / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

7.1: hydrogen / palladium 10% on activated carbon / water; methanol / 760.05 Torr

8.1: acetic acid / methanol / 1 h

8.2: 20 °C / Cooling with ice

With sodium azide; hydrogen; sodium hydride; sodium hydrogencarbonate; acetic acid; triethylamine; calcium chloride; palladium 10% on activated carbon; In methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;