N-benzoyl-2-phenylthiomethylpyrrolidine

Base Information

• Chemical Name: N-benzoyl-2-phenylthiomethylpyrrolidine
• CAS No.: 113261-17-9
• Molecular Formula: C₁₈H₁₉NOS
• Molecular Weight: 297.421
• Mol file: 113261-17-9.mol

Synonyms:N-benzoyl-2-phenylthiomethylpyrrolidine

Chemical Property of N-benzoyl-2-phenylthiomethylpyrrolidine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-benzoyl-2-phenylthiomethylpyrrolidine

There total 4 articles about N-benzoyl-2-phenylthiomethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-benzoyl-2-chloromethylpyrrolidine (1000789-60-5) + thiophenol (108-98-5) → N-benzoyl-2-phenylthiomethylpyrrolidine (113261-17-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jo7015967

Reference yield: 54.0%

N-(pent-4-en-1yl)benzamide (91639-72-4) + diphenyldisulfane (882-33-7) → N-benzoyl-2-phenylthiomethylpyrrolidine (113261-17-9)

Guidance literature:

With manganese triacetate; In dichloromethane; trifluoroacetic acid;

DOI:10.1016/S0040-4039(00)96017-9

Reference yield:

4-Pentenenitrile (592-51-8) → N-benzoyl-2-phenylthiomethylpyrrolidine (113261-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / lithium aluminium hydride / diethyl ether / 2 h

2: sodium hydroxide / H₂O

3: 54 percent / manganese(III) acetate dihydrate, trifluoroacetic acid / CH₂Cl₂ / 4 h / 0 °C

With sodium hydroxide; lithium aluminium tetrahydride; manganese triacetate; trifluoroacetic acid; In diethyl ether; dichloromethane; water;

upstream raw materials:

N-(pent-4-en-1yl)benzamide

diphenyldisulfane

4-Pentenenitrile

4-pentenyl-1-amine