(5(6-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)hexyl)-2H-tetrazol-2-yl)methyl 4-nitrophenyl carbonate

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Chemical Name:(5(6-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)hexyl)-2H-tetrazol-2-yl)methyl 4-nitrophenyl carbonate
CAS No.:1350836-76-8
Molecular Formula:C₂₉H₃₂F₂N₆O₇
Molecular Weight:614.606
Hs Code.:

Synonyms:(5(6-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)hexyl)-2H-tetrazol-2-yl)methyl 4-nitrophenyl carbonate

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Chemical Property of (5(6-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)hexyl)-2H-tetrazol-2-yl)methyl 4-nitrophenyl carbonate

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Technology Process of (5(6-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)hexyl)-2H-tetrazol-2-yl)methyl 4-nitrophenyl carbonate

There total 1 articles about (5(6-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)hexyl)-2H-tetrazol-2-yl)methyl 4-nitrophenyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 634193-54-7
C₂₁H₂₇F₂N₅O₂

: 101623-71-6
iodomethyl(4-nitrophenyl)carbonate

: 1350836-78-0
C₂₉H₃₂F₂N₆O₇

: 1350836-76-8
(5(6-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)hexyl)-2H-tetrazol-2-yl)methyl 4-nitrophenyl carbonate

Guidance literature:: C₂₁H₂₇F₂N₅O₂; With mercury(II) diacetate; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

iodomethyl(4-nitrophenyl)carbonate; In 1,2-dichloro-ethane; for 24h; Reflux;
DOI:10.1016/j.bmc.2012.01.024

Reference yield:

: tetrabutylammonium alendronate

: 1350836-76-8
(5(6-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)hexyl)-2H-tetrazol-2-yl)methyl 4-nitrophenyl carbonate

: 1350836-69-9
C₂₇H₄₀F₂N₆O₁₁P₂

Guidance literature:: tetrabutylammonium alendronate; (5(6-((R)-2-((R,E)-4,4-difluoro-3-hydroxy-4-phenylbut-1-enyl)-5-oxopyrrolidin-1-yl)hexyl)-2H-tetrazol-2-yl)methyl 4-nitrophenyl carbonate; With N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

In water;
DOI:10.1016/j.bmc.2012.01.024