methyl 3-[2-hydroxy-5-(2-{4-[3-(2-trifluoromethyl-phenyl)-ureido]-phenyl}-acetylamino)-phenyl]-propionate

Base Information

• Chemical Name: methyl 3-[2-hydroxy-5-(2-{4-[3-(2-trifluoromethyl-phenyl)-ureido]-phenyl}-acetylamino)-phenyl]-propionate
• CAS No.: 1016274-46-6
• Molecular Formula: C₂₆H₂₄F₃N₃O₅
• Molecular Weight: 515.489
• Mol file: 1016274-46-6.mol

Synonyms:methyl 3-[2-hydroxy-5-(2-{4-[3-(2-trifluoromethyl-phenyl)-ureido]-phenyl}-acetylamino)-phenyl]-propionate

Chemical Property of methyl 3-[2-hydroxy-5-(2-{4-[3-(2-trifluoromethyl-phenyl)-ureido]-phenyl}-acetylamino)-phenyl]-propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-[2-hydroxy-5-(2-{4-[3-(2-trifluoromethyl-phenyl)-ureido]-phenyl}-acetylamino)-phenyl]-propionate

There total 1 articles about methyl 3-[2-hydroxy-5-(2-{4-[3-(2-trifluoromethyl-phenyl)-ureido]-phenyl}-acetylamino)-phenyl]-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-(3-(2-trifluoromethyl)-phenylureido)-phenylacetic acid (317356-45-9) + C10H13NO3 (1016274-45-5) → methyl 3-[2-hydroxy-5-(2-{4-[3-(2-trifluoromethyl-phenyl)-ureido]-phenyl}-acetylamino)-phenyl]-propionate (1016274-46-6)

Guidance literature:

4-(3-(2-trifluoromethyl)-phenylureido)-phenylacetic acid; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

C₁₀H₁₃NO₃; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Further stages.;

DOI:10.1016/j.bmcl.2007.12.006

Reference yield: 32.0%

2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecane-13-yl methanesulfonate (430430-57-2) + methyl 3-[2-hydroxy-5-(2-{4-[3-(2-trifluoromethyl-phenyl)-ureido]-phenyl}-acetylamino)-phenyl]-propionate (1016274-46-6) → C37H45F3N4O9 (1016274-47-7)

Guidance literature:

methyl 3-[2-hydroxy-5-(2-{4-[3-(2-trifluoromethyl-phenyl)-ureido]-phenyl}-acetylamino)-phenyl]-propionate; With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃; for 0.5h;

2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecane-13-yl methanesulfonate; In N,N-dimethyl-formamide; at 65 ℃; for 17h; Further stages.;

DOI:10.1016/j.bmcl.2007.12.006

upstream raw materials:

4-(3-(2-trifluoromethyl)-phenylureido)-phenylacetic acid

C₁₀H₁₃NO₃

Downstream raw materials:

C₃₇H₄₅F₃N₄O₉