3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-[1,2,4]oxadiazol-5-ol

Base Information

Chemical Name:3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-[1,2,4]oxadiazol-5-ol
CAS No.:1345041-94-2
Molecular Formula:C₁₇H₁₃ClN₄O₂
Molecular Weight:340.769
Hs Code.:

Synonyms:3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-[1,2,4]oxadiazol-5-ol

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Chemical Property of 3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-[1,2,4]oxadiazol-5-ol

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Technology Process of 3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-[1,2,4]oxadiazol-5-ol

There total 7 articles about 3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-[1,2,4]oxadiazol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1345041-83-9
5-(4-chlorophenyl)-N-hydroxy-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxamidine

: 541-41-3
chloroformic acid ethyl ester

: 1345041-94-2
3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-[1,2,4]oxadiazol-5-ol

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester

: 1345041-94-2
3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-[1,2,4]oxadiazol-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium hydroxide / tetrahydrofuran; water / 50 - 60 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / 0.33 h / 0 °C

3: hydroxylamine hydrochloride; sodium carbonate / methanol / 6 h / 25 - 30 °C

4: pyridine / dichloromethane / 0.5 h / 0 °C

With pyridine; oxalyl dichloride; hydroxylamine hydrochloride; sodium carbonate; ammonium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 133678-11-2
ethyl 2-oxo-4-(p-chlorophenyl)but-3-enoate

: 1345041-94-2
3-[5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-[1,2,4]oxadiazol-5-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 2 h / 25 - 30 °C / Inert atmosphere

1.2: 10 h / Inert atmosphere; Reflux

2.1: ammonium hydroxide / tetrahydrofuran; water / 50 - 60 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / 0.33 h / 0 °C

4.1: hydroxylamine hydrochloride; sodium carbonate / methanol / 6 h / 25 - 30 °C

5.1: pyridine / dichloromethane / 0.5 h / 0 °C

With pyridine; oxalyl dichloride; hydroxylamine hydrochloride; sodium carbonate; ammonium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.08.061