2-methyl-3-chloropropyl phenyl sulfone

Base Information

• Chemical Name: 2-methyl-3-chloropropyl phenyl sulfone
• CAS No.: 78505-03-0
• Molecular Formula: C₁₀H₁₃ClO₂S
• Molecular Weight: 232.731
• Mol file: 78505-03-0.mol

Synonyms:2-methyl-3-chloropropyl phenyl sulfone

Chemical Property of 2-methyl-3-chloropropyl phenyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-3-chloropropyl phenyl sulfone

There total 1 articles about 2-methyl-3-chloropropyl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

[(3-chloro-2-methylpropyl)sulfanyl]benzene (13012-61-8) → 2-methyl-3-chloropropyl phenyl sulfone (78505-03-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4020(01)92056-3

Reference yield: 46.0%

benzaldehyde (100-52-7) + 2-methyl-3-chloropropyl phenyl sulfone (78505-03-0) → (2S,3R)-3-Benzenesulfonyl-4-methyl-2-phenyl-tetrahydro-furan + 2-Methylcyclopropylphenylsulfon (65288-16-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at -30 ℃;

DOI:10.1007/s11172-005-0043-8

Reference yield:

2-methyl-3-chloropropyl phenyl sulfone (78505-03-0) → (3S)-3-methyl-4-phenylsulfonylbutanol (78505-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaI, 2.) NaOH / 1.) ethanol, water, reflux, 48 h, 2.) water, reflux, 2 h

2: 94 percent / LAH / tetrahydrofuran / 1 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; sodium iodide; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)92056-3

upstream raw materials:

[(3-chloro-2-methylpropyl)sulfanyl]benzene

Downstream raw materials:

3-methyl-4-phenylsulfonylbutanoic acid

R-(-)-3-methyl-4-phenylsulfonylbutanoic acid

S-(+)-3-methyl-4-phenylsulfonylbutanoic acid

2-Methylcyclopropylphenylsulfon