(S)-1-[(2R,3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(2S,6R)-4-methylene-6-(2-triisopropylsilanyloxy-ethyl)-tetrahydro-pyran-2-yl]-propan-2-ol

Base Information

Chemical Name:(S)-1-[(2R,3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(2S,6R)-4-methylene-6-(2-triisopropylsilanyloxy-ethyl)-tetrahydro-pyran-2-yl]-propan-2-ol
CAS No.:365404-37-1
Molecular Formula:C₃₅H₆₀O₅Si
Molecular Weight:588.944
Hs Code.:

(S)-1-[(2R,3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(2S,6R)-4-methylene-6-(2-triisopropylsilanyloxy-ethyl)-tetrahydro-pyran-2-yl]-propan-2-ol

Synonyms:(S)-1-[(2R,3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(2S,6R)-4-methylene-6-(2-triisopropylsilanyloxy-ethyl)-tetrahydro-pyran-2-yl]-propan-2-ol

Suppliers and Price of (S)-1-[(2R,3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(2S,6R)-4-methylene-6-(2-triisopropylsilanyloxy-ethyl)-tetrahydro-pyran-2-yl]-propan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-1-[(2R,3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(2S,6R)-4-methylene-6-(2-triisopropylsilanyloxy-ethyl)-tetrahydro-pyran-2-yl]-propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-1-[(2R,3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(2S,6R)-4-methylene-6-(2-triisopropylsilanyloxy-ethyl)-tetrahydro-pyran-2-yl]-propan-2-ol

There total 19 articles about (S)-1-[(2R,3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(2S,6R)-4-methylene-6-(2-triisopropylsilanyloxy-ethyl)-tetrahydro-pyran-2-yl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 365404-32-6
[(2R,3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-acetaldehyde

: 365404-36-0
(R)-6-Triisopropylsilanyloxy-2-trimethylsilanylmethyl-4-vinyloxy-hex-1-ene

: (R)-1-[(2S,3S,6R)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(2S,6R)-4-methylene-6-(2-triisopropylsilanyloxy-ethyl)-tetrahydro-pyran-2-yl]-propan-2-ol

: 365404-37-1
(S)-1-[(2R,3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(2S,6R)-4-methylene-6-(2-triisopropylsilanyloxy-ethyl)-tetrahydro-pyran-2-yl]-propan-2-ol

Guidance literature:: [(2R,3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-acetaldehyde; With 2,6-di-tert-butyl-pyridine; boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 0.166667h;

(R)-6-Triisopropylsilanyloxy-2-trimethylsilanylmethyl-4-vinyloxy-hex-1-ene; In dichloromethane; at -78 ℃; for 2h;

With sodium tetrahydroborate; In ethanol; for 0.25h; Title compound not separated from byproducts;
DOI:10.1021/ja011377n

Reference yield:

: 365404-52-0
Acetic acid (3S,6S)-6-(2-benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl ester

: 365404-37-1
(S)-1-[(2R,3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(2S,6R)-4-methylene-6-(2-triisopropylsilanyloxy-ethyl)-tetrahydro-pyran-2-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / boron trifluoride etherate / CH₂Cl₂ / 2 h / -78 °C

2.1: 95 percent / triphenylphosphine; ozone / CH₂Cl₂ / 1.25 h / 20 °C

3.1: BF₃*OEt₂; 2,6-di-tert-butylpyridine / CH₂Cl₂ / 0.17 h / -78 °C

3.2: CH₂Cl₂ / 2 h / -78 °C

3.3: 78 percent / sodium borohydride / ethanol / 0.25 h

With 2,6-di-tert-butyl-pyridine; boron trifluoride diethyl etherate; ozone; triphenylphosphine; In dichloromethane;
DOI:10.1021/ja011377n

Reference yield:

: 365404-53-1
(2R,3S,6S)-2-Allyl-6-(2-benzyloxy-ethyl)-3-methyl-tetrahydro-pyran

: 365404-37-1
(S)-1-[(2R,3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl]-3-[(2S,6R)-4-methylene-6-(2-triisopropylsilanyloxy-ethyl)-tetrahydro-pyran-2-yl]-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / triphenylphosphine; ozone / CH₂Cl₂ / 1.25 h / 20 °C

2.1: BF₃*OEt₂; 2,6-di-tert-butylpyridine / CH₂Cl₂ / 0.17 h / -78 °C

2.2: CH₂Cl₂ / 2 h / -78 °C

2.3: 78 percent / sodium borohydride / ethanol / 0.25 h

With 2,6-di-tert-butyl-pyridine; boron trifluoride diethyl etherate; ozone; triphenylphosphine; In dichloromethane;
DOI:10.1021/ja011377n