Acetic acid (3S,6S)-6-(2-benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl ester

Base Information

Chemical Name:Acetic acid (3S,6S)-6-(2-benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl ester
CAS No.:365404-52-0
Molecular Formula:C₁₇H₂₄O₄
Molecular Weight:292.375
Hs Code.:

Synonyms:Acetic acid (3S,6S)-6-(2-benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl ester

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Chemical Property of Acetic acid (3S,6S)-6-(2-benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl ester

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Technology Process of Acetic acid (3S,6S)-6-(2-benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl ester

There total 7 articles about Acetic acid (3S,6S)-6-(2-benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108-24-7
acetic anhydride

: 365404-31-5
(3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-one

: 365404-52-0
Acetic acid (3S,6S)-6-(2-benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl ester

Guidance literature:: (3S,6S)-6-(2-Benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-one; With diisobutylaluminium hydride; In hexane; dichloromethane; for 0.75h;

acetic anhydride; With pyridine; dmap; In hexane; dichloromethane; at -78 - 0 ℃; Further stages.;
DOI:10.1021/ja011377n

Reference yield:

: 365404-50-8
(2S,5S)-7-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-methyl-heptanoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

: 365404-52-0
Acetic acid (3S,6S)-6-(2-benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 77 percent / aq. sulfuric acid / dioxane / 0.5 h / 95 °C

2.1: DIBALH / CH₂Cl₂; hexane / 0.75 h

2.2: 95 percent / pyridine; DMAP / CH₂Cl₂; hexane / -78 - 0 °C

With sulfuric acid; diisobutylaluminium hydride; In 1,4-dioxane; hexane; dichloromethane;
DOI:10.1021/ja011377n

Reference yield:

: 64714-79-0
5-benzyloxy-3-oxo-pentanoic acid ethyl ester

: 365404-52-0
Acetic acid (3S,6S)-6-(2-benzyloxy-ethyl)-3-methyl-tetrahydro-pyran-2-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: H₂; benzeneruthenium (II) chloride dimer; (R)-(+)-BINAP / ethanol; dimethylformamide / 90 h / 20 - 40 °C / 62059.4 Torr

2.1: 86 percent / imidazole / dimethylformamide / 9 h / 20 °C

3.1: 88 percent / DIBALH / CH₂Cl₂; hexane / 0.33 h / -30 - -25 °C

4.1: 100 percent / I₂; PPh₃; imidazole / CH₂Cl₂ / 17 h / 20 °C

5.1: diisopropylamine; LiCl; n-butyllithium / tetrahydrofuran; hexane / 1.33 h / -78 - 20 °C

5.2: 98 percent / tetrahydrofuran; hexane / 20 h / 0 - 20 °C

6.1: 77 percent / aq. sulfuric acid / dioxane / 0.5 h / 95 °C

7.1: DIBALH / CH₂Cl₂; hexane / 0.75 h

7.2: 95 percent / pyridine; DMAP / CH₂Cl₂; hexane / -78 - 0 °C

With 1H-imidazole; dichloro(benzene)ruthenium(II) dimer; n-butyllithium; sulfuric acid; hydrogen; iodine; diisobutylaluminium hydride; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; 1.1: Noyori hydrogenation;
DOI:10.1021/ja011377n