2,2-dimethyl-3-phenylpropanoyl chloride

Base Information

• Chemical Name: 2,2-dimethyl-3-phenylpropanoyl chloride
• CAS No.: 62931-24-2
• Molecular Formula: C₁₁H₁₃ClO
• Molecular Weight: 196.677
• Mol file: 62931-24-2.mol

Synonyms:2,2-dimethyl-3-phenylpropanoyl chloride

Chemical Property of 2,2-dimethyl-3-phenylpropanoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-dimethyl-3-phenylpropanoyl chloride

There total 10 articles about 2,2-dimethyl-3-phenylpropanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,2-dimethyl-3-phenylpropanoic acid (5669-14-7) → 2,2-dimethyl-3-phenylpropanoyl chloride (62931-24-2)

Guidance literature:

With thionyl chloride; In dichloromethane; Inert atmosphere;

DOI:10.1021/acs.organomet.1c00265

Reference yield:

methyl 2,2-dimethyl-3-phenylpropionate (14248-22-7) → 2,2-dimethyl-3-phenylpropanoyl chloride (62931-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / methanol / 60 °C

1.2: pH 2

2.1: thionyl chloride / 3 h / 85 °C / Inert atmosphere

With thionyl chloride; water; sodium hydroxide; In methanol;

DOI:10.1021/ja2001709

Reference yield:

benzyl bromide (100-39-0) → 2,2-dimethyl-3-phenylpropanoyl chloride (62931-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA / 1.) ether, -78 deg C, 30 min, 2.) reflux, 2 d

2: thionyl chloride

With thionyl chloride; lithium diisopropyl amide;

DOI:10.1246/bcsj.64.1145

upstream raw materials:

2,2-dimethyl-3-phenylpropanoic acid

benzyl bromide

2,2-dimethyl-3-phenylpropanenitrile

benzyl chloride

Downstream raw materials:

2,2-dimethyl-indan-1-one

N-methoxy-2,2-dimethyl-3-phenylpropanamide

2,2-dimethyl-3-phenyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)butanamide

2,2-dimethyl-3-phenyl-N-(pyridin-2-ylmethyl)propanamide

Refernces

• 1、 Liu, Junyang,Johnson, Samuel A.. "Mechanism of 8-Aminoquinoline-Directed Ni-Catalyzed C(sp3)-H Functionalization: Paramagnetic Ni(II) Species and the Deleterious Effect of Carbonate as a Base". supporting information. p. 2970 - 2982. Retrieved 2021/06/28.
• 2、 Xiao, Han-Zhi,Wang, Wen-Shu,Sun, Yu-Song,Luo, Hao,Li, Bo-Wen,Wang, Xiao-Dong,Lin, Wei-Li,Luo, Fei-Xian. "Pd/Cu-Catalyzed Cascade C(sp3)-H Arylation and Intramolecular C-N Coupling: A One-Pot Synthesis of 3,4-2 H-Quinolinone Skeletons". supporting information. p. 1668 - 1671. Retrieved 2019/03/11.