(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-10-one

Base Information

Chemical Name:(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-10-one
CAS No.:85924-18-1
Molecular Formula:C₂₆H₂₈N₂O₄S
Molecular Weight:464.585
Hs Code.:

Synonyms:(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-10-one

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Chemical Property of (+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-10-one

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Technology Process of (+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-10-one

There total 4 articles about (+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85924-14-7
cis-4a-ethyl-2,3,4,4a,5,6,7,11c-octahydro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole

: 85924-18-1
(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-10-one

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / aq. NaOH / CH₂Cl₂ / 0.25 h / 0 °C

2: aq. sodium bicarbonate, m-chloroperbenzoic acid / CH₂Cl₂ / 1.25 h / 0 °C

3: 1.) trifluoroacetic anhydride, 3.) Raney nickel W-2 / 1.) methylene chloride, 0 deg c, 15 min, 2.) chlorobenzene, 0 deg C -> 135 deg C, 1 h; 135 deg C, 1.25 h; 3.) dimethylformamide, ethanol, 20 deg C, 20 min

With sodium hydroxide; Raney nickel W-2; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In dichloromethane;
DOI:10.1021/ja00352a038

Reference yield:

: 85924-16-9
1-[(4aR,11cR)-4a-Ethyl-7-(4-methoxy-benzenesulfonyl)-2,3,4,4a,5,6,7,11c-octahydro-pyrido[3,2-c]carbazol-1-yl]-2-phenylsulfanyl-ethanone

: 85924-18-1
(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-10-one

Guidance literature:: Multi-step reaction with 2 steps

1: aq. sodium bicarbonate, m-chloroperbenzoic acid / CH₂Cl₂ / 1.25 h / 0 °C

2: 1.) trifluoroacetic anhydride, 3.) Raney nickel W-2 / 1.) methylene chloride, 0 deg c, 15 min, 2.) chlorobenzene, 0 deg C -> 135 deg C, 1 h; 135 deg C, 1.25 h; 3.) dimethylformamide, ethanol, 20 deg C, 20 min

With Raney nickel W-2; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In dichloromethane;
DOI:10.1021/ja00352a038

Reference yield:

: 85923-70-2
2,2,2-trichloroethyl cis-2,3,4,4a,5,6,7,11c-octahydro-4a-ethyl-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole-1-carboxylate

: 85924-18-1
(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>aspidospermidin-10-one

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / zinc, acetic acid / H₂O / 4 h

2: 50 percent / aq. NaOH / CH₂Cl₂ / 0.25 h / 0 °C

3: aq. sodium bicarbonate, m-chloroperbenzoic acid / CH₂Cl₂ / 1.25 h / 0 °C

4: 1.) trifluoroacetic anhydride, 3.) Raney nickel W-2 / 1.) methylene chloride, 0 deg c, 15 min, 2.) chlorobenzene, 0 deg C -> 135 deg C, 1 h; 135 deg C, 1.25 h; 3.) dimethylformamide, ethanol, 20 deg C, 20 min

With sodium hydroxide; Raney nickel W-2; sodium hydrogencarbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; zinc; In dichloromethane; water;
DOI:10.1021/ja00352a038