1-Benzenesulfonyl-5-bromo-3-[2-(1-methyl-piperidin-4-yl)-thiazol-4-yl]-1H pyrrolo[2,3-b]pyridine

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Chemical Name:1-Benzenesulfonyl-5-bromo-3-[2-(1-methyl-piperidin-4-yl)-thiazol-4-yl]-1H pyrrolo[2,3-b]pyridine
CAS No.:1046793-45-6
Molecular Formula:C₂₂H₂₁BrN₄O₂S₂
Molecular Weight:517.47
Hs Code.:

Synonyms:1-Benzenesulfonyl-5-bromo-3-[2-(1-methyl-piperidin-4-yl)-thiazol-4-yl]-1H pyrrolo[2,3-b]pyridine

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Chemical Property of 1-Benzenesulfonyl-5-bromo-3-[2-(1-methyl-piperidin-4-yl)-thiazol-4-yl]-1H pyrrolo[2,3-b]pyridine

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Technology Process of 1-Benzenesulfonyl-5-bromo-3-[2-(1-methyl-piperidin-4-yl)-thiazol-4-yl]-1H pyrrolo[2,3-b]pyridine

There total 3 articles about 1-Benzenesulfonyl-5-bromo-3-[2-(1-methyl-piperidin-4-yl)-thiazol-4-yl]-1H pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1046793-44-5
4-(5-bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-(piperidin-4-yl)thiazole

: 1046793-45-6
1-Benzenesulfonyl-5-bromo-3-[2-(1-methyl-piperidin-4-yl)-thiazol-4-yl]-1H pyrrolo[2,3-b]pyridine

Guidance literature:: formaldehyd; 4-(5-bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-(piperidin-4-yl)thiazole; With acetic acid; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; water; at 20 ℃;

With water; sodium hydrogencarbonate; In tetrahydrofuran; for 0.333333h; Product distribution / selectivity;

Reference yield: 63.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1046793-43-4
4-[4-(1-Benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

: 1046793-45-6
1-Benzenesulfonyl-5-bromo-3-[2-(1-methyl-piperidin-4-yl)-thiazol-4-yl]-1H pyrrolo[2,3-b]pyridine

Guidance literature:: 4-[4-(1-Benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-thiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; for 1h;

formaldehyd; With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; water;

With hydrogenchloride; water; In tetrahydrofuran; Product distribution / selectivity;