1,6:3,4-bis(2-oxapropylene)tetrahydro-3a,6a-bis(4-methoxyphenyl)imidazo[4,5-d]imidazole-2,5-(1H,3H)dione

Base Information

Chemical Name:1,6:3,4-bis(2-oxapropylene)tetrahydro-3a,6a-bis(4-methoxyphenyl)imidazo[4,5-d]imidazole-2,5-(1H,3H)dione
CAS No.:663908-75-6
Molecular Formula:C₂₂H₂₂N₄O₆
Molecular Weight:438.44
Hs Code.:

Synonyms:1,6:3,4-bis(2-oxapropylene)tetrahydro-3a,6a-bis(4-methoxyphenyl)imidazo[4,5-d]imidazole-2,5-(1H,3H)dione

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Chemical Property of 1,6:3,4-bis(2-oxapropylene)tetrahydro-3a,6a-bis(4-methoxyphenyl)imidazo[4,5-d]imidazole-2,5-(1H,3H)dione

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Technology Process of 1,6:3,4-bis(2-oxapropylene)tetrahydro-3a,6a-bis(4-methoxyphenyl)imidazo[4,5-d]imidazole-2,5-(1H,3H)dione

There total 2 articles about 1,6:3,4-bis(2-oxapropylene)tetrahydro-3a,6a-bis(4-methoxyphenyl)imidazo[4,5-d]imidazole-2,5-(1H,3H)dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 663908-73-4
3a,6a-bis(4-methoxyphenyl)-tetrahydroimidazo[4,5-d]imidazole-2,5-(1H,3H)-dione

: 663908-75-6
1,6:3,4-bis(2-oxapropylene)tetrahydro-3a,6a-bis(4-methoxyphenyl)imidazo[4,5-d]imidazole-2,5-(1H,3H)dione

Guidance literature:: formaldehyd; 3a,6a-bis(4-methoxyphenyl)-tetrahydroimidazo[4,5-d]imidazole-2,5-(1H,3H)-dione; With sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 18h; pH=9;

With hydrogenchloride; In dimethyl sulfoxide; for 2h; pH=1; Further stages.; Heating;
DOI:10.1016/j.tet.2003.10.084

Reference yield:

: 1226-42-2
1,2-bis(4-methoxyphenyl)-1,2-ethanedione

: 663908-75-6
1,6:3,4-bis(2-oxapropylene)tetrahydro-3a,6a-bis(4-methoxyphenyl)imidazo[4,5-d]imidazole-2,5-(1H,3H)dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / TFA / toluene / 4 h / Heating

2.1: aq. NaOH / dimethylsulfoxide / 18 h / 20 °C / pH 9

2.2: 99 percent / hydrochloric acid / dimethylsulfoxide / 2 h / pH 1 / Heating

With sodium hydroxide; trifluoroacetic acid; In dimethyl sulfoxide; toluene;
DOI:10.1016/j.tet.2003.10.084

Reference yield: 97.0%

: 123-31-9,8027-02-9
hydroquinone

: 663908-75-6
1,6:3,4-bis(2-oxapropylene)tetrahydro-3a,6a-bis(4-methoxyphenyl)imidazo[4,5-d]imidazole-2,5-(1H,3H)dione

: 1,6:3,4-bis(3,6-dihydroxy-1,2-xylylene)tetrahydro-3a,6a-bis(4-methoxy-phenyl)imidazo[4,5-d]imidazole-2,5(1H,3H)dione

Guidance literature:: 1,6:3,4-bis(2-oxapropylene)tetrahydro-3a,6a-bis(4-methoxyphenyl)imidazo[4,5-d]imidazole-2,5-(1H,3H)dione; With 4 A molecular sieve; toluene-4-sulfonic acid; In 1,2-dichloro-ethane; for 0.166667h; Heating;

hydroquinone; In 1,2-dichloro-ethane; for 2h; Further stages.; Heating;
DOI:10.1016/j.tet.2003.10.084