N-(4-(butylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanecarboxamide

Base Information

Chemical Name:N-(4-(butylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanecarboxamide
CAS No.:1415565-41-1
Molecular Formula:C₁₇H₂₅N₅O
Molecular Weight:315.418
Hs Code.:

Synonyms:N-(4-(butylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(butylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanecarboxamide

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Technology Process of N-(4-(butylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanecarboxamide

There total 4 articles about N-(4-(butylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1415565-36-4
N⁴-butyl-5H-pyrrolo[3,2-d]pyrimidine-4,7-diamine

: 2719-27-9
cyclohexanylcarbonyl chloride

: 1415565-41-1
N-(4-(butylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1021/co300106f

Reference yield:

: 1415565-24-0
n-butyl-7-nitro-5H-pyrrolo[3,2-d]pyrimidin-4-amine

: 1415565-41-1
N-(4-(butylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 20 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/co300106f

Reference yield:

: 1260676-83-2
4-chloro-7-nitro-5H-pyrrolo[3,2-d]pyrimidine

: 1415565-41-1
N-(4-(butylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 80 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 20 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/co300106f