Chemical Property of Triflusal
Chemical Property:
- Vapor Pressure:0.000178mmHg at 25°C
- Melting Point:120-122° (upon slow heating); 110-112° (upon quick heating)
- Refractive Index:1.483
- Boiling Point:316 °C at 760 mmHg
- PKA:2.97±0.10(Predicted)
- Flash Point:144.9 °C
- Density:1.433 g/cm3
- Storage Temp.:2-8°C
- Solubility.:DMSO: >30mg/mL
- XLogP3:2.1
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:3
- Exact Mass:248.02964319
- Heavy Atom Count:17
- Complexity:313
- Purity/Quality:
-
99% *data from raw suppliers
Triflusal *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22-36/37/38-43
- Safety Statements:
26-36/37
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(=O)OC1=C(C=CC(=C1)C(F)(F)F)C(=O)O
- Recent ClinicalTrials:ASpirin vs Triflusal for Event Reduction In Atherothrombosis Secondary Prevention (ASTERIAS)
- Recent EU Clinical Trials:Evaluación del tratamiento con triflusal en pacientes con cardiopatía isquémica estable con no respuesta a AAS
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Description
Triflusal is an antiplatelet agent structurally related to the salicylates, but it is not derived from ASA. Triflusal and its metabolite (3-hydroxy-4-triuoro-methylbenzoic acid or HTB) produce specic inhibition of platelet arachidonic acid metabolism (McNeely and Goa, 1998). A single 12-month open-label trial of Triflusal in 73 VaD patients (López-Pousa et al., 1997) showed fewer declines in MMSE scores in the active group compared with untreated subjects. More recently, Triflusal was used in patients with amnesic MCI; 257 patients were randomized to receive 900 mg of Triflusal or placebo for 18 months. Triflusal therapy was associated with a signicantly lower rate of conversion to dementia (Gómez-Isla et al., 2008).
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Uses
An analog of Aspirin; inhibits platelet aggregation. Antithrombotic. Antithrombotic;Cyclooxygenase inhibitor
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Clinical Use
Triflusal (2-acetoxy-4-trifluoromethyl benzoic acid) is an antiplatelet drug that despite its structural
similarity to aspirin exhibits quite different pharmacological and pharmacokinetic
properties.
