methyl 2-ethyl-4-(4-fluoro-3-iodophenyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridin-3-carboxylate

Base Information

• Chemical Name: methyl 2-ethyl-4-(4-fluoro-3-iodophenyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridin-3-carboxylate
• CAS No.: 497098-26-7
• Molecular Formula: C₁₈H₁₇FINO₄
• Molecular Weight: 457.24
• Mol file: 497098-26-7.mol

Synonyms:methyl 2-ethyl-4-(4-fluoro-3-iodophenyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridin-3-carboxylate

Chemical Property of methyl 2-ethyl-4-(4-fluoro-3-iodophenyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridin-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-ethyl-4-(4-fluoro-3-iodophenyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridin-3-carboxylate

There total 5 articles about methyl 2-ethyl-4-(4-fluoro-3-iodophenyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridin-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2H-pyran-3,5(4H,6H)-dione (61363-56-2) + 3-aminopent-2-enoic acid methyl ester (124413-61-2) + 4-fluoro-3-iodobenzaldehyde (227609-88-3) → methyl 2-ethyl-4-(4-fluoro-3-iodophenyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridin-3-carboxylate (497098-26-7)

Guidance literature:

In ethanol; at 80 ℃; for 16h;

DOI:10.1021/jm060549u

Reference yield:

methyl 2-(prop-2-yn-1-yloxy)acetate (67500-49-6) → methyl 2-ethyl-4-(4-fluoro-3-iodophenyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridin-3-carboxylate (497098-26-7)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄ / Hg(OAc)2 / methanol / 1 h / Heating

2: KO-t-Bu / 2-methyl-propan-2-ol; diethyl ether / 0.17 h / 0 °C

3: 72 percent / ethanol / 16 h / 80 °C

With sulfuric acid; potassium tert-butylate; mercury(II) diacetate; In methanol; diethyl ether; ethanol; tert-butyl alcohol;

DOI:10.1021/jm060549u

Reference yield:

methyl propanoyl acetate (30414-53-0) → methyl 2-ethyl-4-(4-fluoro-3-iodophenyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridin-3-carboxylate (497098-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NH₃ / ethanol / 16 h / 80 °C

2: 72 percent / ethanol / 16 h / 80 °C

With ammonium hydroxide; In ethanol;

DOI:10.1021/jm060549u

upstream raw materials:

2H-pyran-3,5(4H,6H)-dione

3-aminopent-2-enoic acid methyl ester

4-fluoro-3-iodobenzaldehyde

methyl propanoyl acetate