PYRAN-3,5-DIONE

Base Information

• Chemical Name: PYRAN-3,5-DIONE
• CAS No.: 61363-56-2
• Molecular Formula: C5H6O3
• Molecular Weight: 114.101
• Hs Code.: 2932999099
• Mol file: 61363-56-2.mol

Synonyms:NSC 293808;Tetrahydropyran-3,5-dione;

Chemical Property of PYRAN-3,5-DIONE

Chemical Property:

• Vapor Pressure: 0.00776mmHg at 25°C
• Melting Point: 128-129 °C(Solv: ethyl acetate (141-78-6))
• Refractive Index: 1.714
• Boiling Point: 275.1 °C at 760 mmHg
• PKA: 9.24±0.20(Predicted)
• Flash Point: 123.4 °C
• PSA: 43.37000
• Density: 1.26 g/cm³
• LogP: -0.45510
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Pyran-3,5-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYRAN-3,5-DIONE

There total 6 articles about PYRAN-3,5-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(2-oxopropoxy)acetic acid methyl ester (61363-66-4) → 2H-pyran-3,5(4H,6H)-dione (61363-56-2)

Guidance literature:

With sodium t-butanolate; In tetrahydrofuran; at 65 ℃; for 1.08333h;

DOI:10.1021/jo052226w

Reference yield:

methyl 2-(prop-2-yn-1-yloxy)acetate (67500-49-6) → 2H-pyran-3,5(4H,6H)-dione (61363-56-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄ / Hg(OAc)2 / methanol / 1 h / Heating

2: KO-t-Bu / 2-methyl-propan-2-ol; diethyl ether / 0.17 h / 0 °C

With sulfuric acid; potassium tert-butylate; mercury(II) diacetate; In methanol; diethyl ether; tert-butyl alcohol;

DOI:10.1021/jm060549u

Reference yield:

ethyl 2-(2-oxopropoxy)acetate → 2H-pyran-3,5(4H,6H)-dione (61363-56-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 65 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/jm400768f

upstream raw materials:

(2-oxopropoxy)acetic acid methyl ester

methyl 2-(prop-2-yn-1-yloxy)acetate

[(2-methylprop-2-en-1-yl)oxy]acetic acid

methyl [(2-methylprop-2-en-1-yl)oxy]acetate

Downstream raw materials:

methyl 4-(3-bromo-4-fluorophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate

5-(3-cyanophenyl)-5,10-dihydro-1H,3H-dipyrano[3,4-b:4,3-e]pyridine-4,6(7H,9H)-dione