(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-ylamine hydrochloride

Base Information

• Chemical Name: (3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-ylamine hydrochloride
• CAS No.: 882030-12-8
• Molecular Formula: C₁₄H₂₁NO₂S*ClH
• Molecular Weight: 303.853
• Mol file: 882030-12-8.mol

Synonyms:(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-ylamine hydrochloride

Chemical Property of (3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-ylamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-ylamine hydrochloride

There total 13 articles about (3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-ylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-yl]-((R)-1-phenyl-ethyl)-amine hydrochloride (882030-13-9) → (3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-ylamine hydrochloride (882030-12-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 10h; under 82.5083 Torr; Heating / reflux;

Reference yield:

(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-N-[(1R)-1-(4-methoxy-phenyl)-ethyl]-tetrahydro-2H-thiopyran-4-amine hydrochloride → (3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-ylamine hydrochloride (882030-12-8)

Guidance literature:

(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-N-[(1R)-1-(4-methoxy-phenyl)-ethyl]-tetrahydro-2H-thiopyran-4-amine hydrochloride; With trifluoroacetic acid; at 20 ℃; for 0.5h;

With sodium hydroxide; In diethyl ether; water; at 20 ℃; pH=10;

Reference yield:

3-(3-ethoxy-4-methoxyphenyl)tetrahydrothiopyran-4-one (882030-14-0) → (3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-ylamine hydrochloride (882030-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 15 h / 20 °C

1.2: 20 - 60 °C

2.1: trifluoroacetic acid / 0.5 h / 20 °C

2.2: 20 °C / pH 10

With sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; In dichloromethane;

upstream raw materials:

[(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-yl]-((R)-1-phenyl-ethyl)-amine hydrochloride

3-(3-ethoxy-4-methoxyphenyl)tetrahydrothiopyran-4-one

3-(3-ethoxy-4-methoxy-phenyl)-1-methyl-piperidin-4-one

3-ethoxy-4-methoxyphenylacetylene

Downstream raw materials:

methyl 3-{[(3R,4R)-3-(3-ethoxy-4-methoxyphenyl)tetrahydro-2H-thiopyran-4-yl]carbamoyl}benzoate

methyl 4-{[(3R,4R)-3-(3-ethoxy-4-methoxyphenyl)tetrahydro-2H-thiopyran-4-yl]carbamoyl}benzoate

3-(1-{4-[(4aR,10bR)-9-ethoxy-8-methoxy-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoyl}piperidin-4-yl)-1-(3-fluoro-4-methoxybenzyl)-6-phenyl-thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

1-(3,5-difluoro-4-methoxybenzyl)-3-[1-({3-[(4aR,10bR)-9-ethoxy-8-methoxy-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]phenyl}carbonyl)piperidin-4-yl]-6-phenylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione