[(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-yl]-((R)-1-phenyl-ethyl)-amine hydrochloride

Base Information

• Chemical Name: [(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-yl]-((R)-1-phenyl-ethyl)-amine hydrochloride
• CAS No.: 882030-13-9
• Molecular Formula: C₂₂H₂₉NO₂S*ClH
• Molecular Weight: 408.005
• Mol file: 882030-13-9.mol

Synonyms:[(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-yl]-((R)-1-phenyl-ethyl)-amine hydrochloride

Chemical Property of [(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-yl]-((R)-1-phenyl-ethyl)-amine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-yl]-((R)-1-phenyl-ethyl)-amine hydrochloride

There total 6 articles about [(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-yl]-((R)-1-phenyl-ethyl)-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3-ethoxy-4-methoxyphenyl)tetrahydrothiopyran-4-one (882030-14-0) + (R)-1-phenyl-ethyl-amine (3886-69-9) → [(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-yl]-((R)-1-phenyl-ethyl)-amine hydrochloride (882030-13-9)

Guidance literature:

3-(3-ethoxy-4-methoxyphenyl)tetrahydrothiopyran-4-one; (R)-1-phenyl-ethyl-amine; With sodium tetrahydroborate; 2-methylhexanoic acid; In dichloromethane; at 20 ℃;

With sodium hydroxide; In dichloromethane; water;

With hydrogenchloride; In hexane; Isopropyl acetate; isopropyl alcohol;

Reference yield:

3-ethoxy-4-methoxyphenylacetylene (881919-82-0) → [(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-yl]-((R)-1-phenyl-ethyl)-amine hydrochloride (882030-13-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogen bromide; acetic acid / 0.25 h

2.1: tert.-butyl lithium / tetrahydrofuran / 1.5 h / -78 °C

2.2: 1.5 h / -78 - 20 °C

3.1: manganese(IV) oxide / dichloromethane / 0.58 - 1 h / 20 °C

4.1: sodium sulfide / tetrahydrofuran; water / 3 h / 55 °C

5.1: sodium tetrahydroborate; 2-methylhexanoic acid / dichloromethane / 20 °C

With manganese(IV) oxide; sodium sulfide; sodium tetrahydroborate; 2-methylhexanoic acid; hydrogen bromide; tert.-butyl lithium; acetic acid; In tetrahydrofuran; dichloromethane; water;

Reference yield:

1-bromo-1-(3-ethoxy-4-methoxyphenyl)ethene (881919-79-5) → [(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-yl]-((R)-1-phenyl-ethyl)-amine hydrochloride (882030-13-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tert.-butyl lithium / tetrahydrofuran / 1.5 h / -78 °C

1.2: 1.5 h / -78 - 20 °C

2.1: manganese(IV) oxide / dichloromethane / 0.58 - 1 h / 20 °C

3.1: sodium sulfide / tetrahydrofuran; water / 3 h / 55 °C

4.1: sodium tetrahydroborate; 2-methylhexanoic acid / dichloromethane / 20 °C

With manganese(IV) oxide; sodium sulfide; sodium tetrahydroborate; 2-methylhexanoic acid; tert.-butyl lithium; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

3-(3-ethoxy-4-methoxyphenyl)tetrahydrothiopyran-4-one

(R)-1-phenyl-ethyl-amine

3-ethoxy-4-methoxyphenylacetylene

1-bromo-1-(3-ethoxy-4-methoxyphenyl)ethene

Downstream raw materials:

(3R,4R)-3-(3-ethoxy-4-methoxy-phenyl)-tetrahydro-thiopyran-4-ylamine hydrochloride

Refernces