(3S,5S)-5-tert-butoxycarbonylamino-6-cyclohexyl-3-methyl-4-oxohexanoic acid methylester

Base Information

Chemical Name:(3S,5S)-5-tert-butoxycarbonylamino-6-cyclohexyl-3-methyl-4-oxohexanoic acid methylester
CAS No.:133956-89-5
Molecular Formula:C₁₉H₃₃NO₅
Molecular Weight:355.475
Hs Code.:

Synonyms:(3S,5S)-5-tert-butoxycarbonylamino-6-cyclohexyl-3-methyl-4-oxohexanoic acid methylester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,5S)-5-tert-butoxycarbonylamino-6-cyclohexyl-3-methyl-4-oxohexanoic acid methylester

Chemical Property:

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Technology Process of (3S,5S)-5-tert-butoxycarbonylamino-6-cyclohexyl-3-methyl-4-oxohexanoic acid methylester

There total 1 articles about (3S,5S)-5-tert-butoxycarbonylamino-6-cyclohexyl-3-methyl-4-oxohexanoic acid methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133956-87-3
(4S)-4-tert-butoxycarbonylamino-5-cyclohexylpentan-3-one

: 96-32-2
bromoacetic acid methyl ester

: 133956-89-5
(3S,5S)-5-tert-butoxycarbonylamino-6-cyclohexyl-3-methyl-4-oxohexanoic acid methylester

Guidance literature:: With triisopropoxytitanium(IV) chloride; lithium diisopropyl amide; Yield given. Multistep reaction; 1) THF, -70 deg C, 2 h; 2) THF, -70 deg C to 0 deg C;
DOI:10.1016/S0040-4020(01)96101-0

Reference yield: 69.9%

: 133956-89-5
(3S,5S)-5-tert-butoxycarbonylamino-6-cyclohexyl-3-methyl-4-oxohexanoic acid methylester

: 133956-91-9
(4S,5S)-5-<(1S)-1-tert-butoxycarbonylamino-2-cyclohexylethyl>-4-methyltetrahydrofuran-2-one

: 133956-94-2
(3S,4R,5S)-5-tert-butoxycarbonylamino-6-cyclohexyl-4-hydroxy-3-methylhexanoic acid methylester

Guidance literature:: In isopropyl alcohol; at -50 ℃; for 0.5h;
DOI:10.1016/S0040-4020(01)96101-0

Reference yield:

: 133956-89-5
(3S,5S)-5-tert-butoxycarbonylamino-6-cyclohexyl-3-methyl-4-oxohexanoic acid methylester

: 133956-95-3
(3S,4S,5S)-3-benzyl-5-<(1S)-tert-butoxycarbonylamino-2-cyclohexylethyl>-tetrahydrofuran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 16.8 percent / propan-2-ol / 0.5 h / -50 °C

2: 1) lithium hexamethyldisilazide (LiHMDS) / 1) THF, -78 deg C, 15 min., 2) THF, -78 to -40 deg C, 2 h

With lithium hexamethyldisilazane; In isopropyl alcohol;
DOI:10.1016/S0040-4020(01)96101-0