133956-95-3

Upstream product

• 133956-89-5 (3S,5S)-5-tert-butoxycarbonylamino-6-cyclohexyl-3-methyl-4-oxohexanoic acid methylester 
• 115766-13-7 (S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]-N-methoxy-N-methylcyclohexanepropanamide 
• 133956-87-3 (4S)-4-tert-butoxycarbonylamino-5-cyclohexylpentan-3-one 
• 100-39-0 benzyl bromide 
• 133956-91-9 (4S,5S)-5-<(1S)-1-tert-butoxycarbonylamino-2-cyclohexylethyl>-4-methyltetrahydrofuran-2-one 

Relevant academic research and scientific papers

A convenient approach to hydroxyethylene dipeptide isosteres as building blocks for enzyme inhibitors

γ-Lactones 6,8,10 and the ester 9, precursors to the hydroxyethylene dipeptide isostere unit, were synthesized stereoselectively in two or three steps from α-amino-ketones in good yield. Peptides containing these isosteres are potent inhibitors of certain aspartyl proteinases. Alkylation of the (3S,4S)substituted γ-lactone 6 afforded exclusively cis-alkylation, with regard to C-2 and C-4.