Benzoic acid (R)-1-((R)-bromo-methoxycarbonyl-methyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl ester

Base Information

Chemical Name:Benzoic acid (R)-1-((R)-bromo-methoxycarbonyl-methyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl ester
CAS No.:160146-92-9
Molecular Formula:C₂₂H₂₀BrNO₆
Molecular Weight:474.308
Hs Code.:

Synonyms:Benzoic acid (R)-1-((R)-bromo-methoxycarbonyl-methyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl ester

Suppliers and Price of Benzoic acid (R)-1-((R)-bromo-methoxycarbonyl-methyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzoic acid (R)-1-((R)-bromo-methoxycarbonyl-methyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzoic acid (R)-1-((R)-bromo-methoxycarbonyl-methyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl ester

There total 5 articles about Benzoic acid (R)-1-((R)-bromo-methoxycarbonyl-methyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1053615-20-5
(4S,5R)-5-[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-2-methoxy-2-phenyl-[1,3]dioxolane-4-carboxylic acid methyl ester

: 160146-92-9
Benzoic acid (R)-1-((R)-bromo-methoxycarbonyl-methyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl ester

Guidance literature:: With Acetyl bromide; triethylamine; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/jo00098a047

Reference yield:

: 1054605-84-3
(4S,5R)-5-[3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-2-phenyl-[1,3]dioxolane-4-carboxylic acid methyl ester

: 160146-92-9
Benzoic acid (R)-1-((R)-bromo-methoxycarbonyl-methyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl ester

Guidance literature:: With N-Bromosuccinimide; In dichloromethane;
DOI:10.1021/jo00098a047

Reference yield:

: 3598-60-5
4-phthalimidobutanal

: 160146-92-9
Benzoic acid (R)-1-((R)-bromo-methoxycarbonyl-methyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / CH₂Cl₂ / 1 h

2: 96.3 percent / K₃Fe(CN)6, K₂CO₃, K₂Os(OH)3, (DHQD)2-PHAL / 2-methyl-propan-2-ol; H₂O; CH₂Cl₂ / 4 h

3: BF₃*OEt₂

4: NBS / CH₂Cl₂

With N-Bromosuccinimide; K₂Os(OH)3; boron trifluoride diethyl etherate; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III); In dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo00098a047