1,1-dimethylethyl {(3S)-1-[2-cyano-4-(1-pyrrolidinyl)phenyl]-3-pyrrolidinyl}carbamate

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Chemical Name:1,1-dimethylethyl {(3S)-1-[2-cyano-4-(1-pyrrolidinyl)phenyl]-3-pyrrolidinyl}carbamate
CAS No.:1269407-97-7
Molecular Formula:C₂₀H₂₈N₄O₂
Molecular Weight:356.468
Hs Code.:

Synonyms:1,1-dimethylethyl {(3S)-1-[2-cyano-4-(1-pyrrolidinyl)phenyl]-3-pyrrolidinyl}carbamate

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Chemical Property of 1,1-dimethylethyl {(3S)-1-[2-cyano-4-(1-pyrrolidinyl)phenyl]-3-pyrrolidinyl}carbamate

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Technology Process of 1,1-dimethylethyl {(3S)-1-[2-cyano-4-(1-pyrrolidinyl)phenyl]-3-pyrrolidinyl}carbamate

There total 2 articles about 1,1-dimethylethyl {(3S)-1-[2-cyano-4-(1-pyrrolidinyl)phenyl]-3-pyrrolidinyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1269407-95-5
2-bromo-5-(1-pyrrolidinyl)benzonitrile

: 122536-76-9,140629-77-2
3(S)-(tert-butoxycarbonylamino)pyrrolidine

: 1269407-97-7
1,1-dimethylethyl {(3S)-1-[2-cyano-4-(1-pyrrolidinyl)phenyl]-3-pyrrolidinyl}carbamate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 14.5h; Inert atmosphere;

Reference yield:

: 57381-39-2
2-bromo-5-fluorobenzonitrile

: 1269407-97-7
1,1-dimethylethyl {(3S)-1-[2-cyano-4-(1-pyrrolidinyl)phenyl]-3-pyrrolidinyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 100 °C / Sealed vial

2: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 14.5 h / 100 °C / Inert atmosphere

With potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dimethyl sulfoxide; toluene;