2-bromo-5-(1-pyrrolidinyl)benzonitrile

Base Information

Chemical Name:2-bromo-5-(1-pyrrolidinyl)benzonitrile
CAS No.:1269407-95-5
Molecular Formula:C11H11BrN2
Molecular Weight:251.126
Hs Code.:
Mol file:1269407-95-5.mol

Synonyms:2-bromo-5-(1-pyrrolidinyl)benzonitrile;2-Bromo-5-(pyrrolidin-1-yl)benzonitrile

Suppliers and Price of 2-bromo-5-(1-pyrrolidinyl)benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 2-bromo-5-(1-pyrrolidinyl)benzonitrile

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 2-bromo-5-(1-pyrrolidinyl)benzonitrile

There total 1 articles about 2-bromo-5-(1-pyrrolidinyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 123-75-1
pyrrolidine

: 57381-39-2
2-bromo-5-fluorobenzonitrile

: 1269407-95-5
2-bromo-5-(1-pyrrolidinyl)benzonitrile

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 100 ℃; Sealed vial;

Reference yield: 81.0%

: 1269407-95-5
2-bromo-5-(1-pyrrolidinyl)benzonitrile

: 122536-76-9,140629-77-2
3(S)-(tert-butoxycarbonylamino)pyrrolidine

: 1269407-97-7
1,1-dimethylethyl {(3S)-1-[2-cyano-4-(1-pyrrolidinyl)phenyl]-3-pyrrolidinyl}carbamate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 14.5h; Inert atmosphere;

Reference yield:

: 1269407-95-5
2-bromo-5-(1-pyrrolidinyl)benzonitrile

: 1269407-99-9
2-[(3S)-3-amino-1-pyrrolidinyl]-5-(1-pyrrolidinyl)benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 14.5 h / 100 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; toluene;