HU 912

Base Information

• Chemical Name: HU 912
• CAS No.: 1309372-78-8
• Molecular Formula: C₂₈H₄₂O₄
• Molecular Weight: 442.639
• Mol file: 1309372-78-8.mol

Synonyms:HU 912

Chemical Property of HU 912

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of HU 912

There total 9 articles about HU 912 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

→ HU 912 (1309372-78-8)

Guidance literature:

Reference yield:

C17H27BrO2Zn + methyl (1S,4R)-7,7-dimethyl-2-(trifluoromethylsulfonyloxy)bicyclo[2.2.1]hept-2-ene-1-carboxylate (328123-48-4) → HU 912 (1309372-78-8)

Guidance literature:

C₁₇H₂₇BrO₂Zn; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; at 15 ℃; for 0.25h; Large scale;

methyl (1S,4R)-7,7-dimethyl-2-(trifluoromethylsulfonyloxy)bicyclo[2.2.1]hept-2-ene-1-carboxylate; In tetrahydrofuran; hexane; at 15 - 25 ℃; Large scale;

Reference yield:

2-(3,5-dimethoxyphenyl)-2-methylpropanal (120078-30-0) → HU 912 (1309372-78-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 3.08 h / 0 - 5 °C

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 30 °C / 3000.3 Torr

3.1: n-butyllithium / tetrahydrofuran; hexane / 2.08 h / 15 °C / Large scale

3.2: 1.33 h / 15 °C / Large scale

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; hexane / 0.25 h / 15 °C / Large scale

4.2: 15 - 25 °C / Large scale

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; In tetrahydrofuran; hexane; ethyl acetate; 1.1: |Wittig Olefination / 4.1: |Negishi Coupling / 4.2: |Negishi Coupling;

upstream raw materials:

α,α-dimethyl-3,5-dimethoxyphenylacetonitrile

2-(3,5-dimethoxyphenyl)-2-methylpropanal

(1S)-(+)-ketopinic acid

(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylic acid methylester

Downstream raw materials:

HU 910

HU 914