[1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl](4-methoxyphenyl)methanone

Base Information

Chemical Name:[1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl](4-methoxyphenyl)methanone
CAS No.:1594781-87-9
Molecular Formula:C₁₈H₁₄FNO₃
Molecular Weight:311.312
Hs Code.:

Synonyms:[1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl](4-methoxyphenyl)methanone

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Chemical Property of [1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl](4-methoxyphenyl)methanone

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Technology Process of [1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl](4-methoxyphenyl)methanone

There total 3 articles about [1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl](4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1339084-93-3
2-fluoro-4-(1H-pyrrol-1-yl)phenol

: 100-07-2
4-methoxy-benzoyl chloride

: 1594781-87-9
[1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl](4-methoxyphenyl)methanone

: C₂₆H₂₀FNO₅

Guidance literature:: 4-methoxy-benzoyl chloride; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 20 ℃; for 0.25h; Inert atmosphere;

2-fluoro-4-(1H-pyrrol-1-yl)phenol; In 1,2-dichloro-ethane; at 20 ℃; for 4.5h; Inert atmosphere;

With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2014.02.016

Reference yield:

: 1339084-93-3
2-fluoro-4-(1H-pyrrol-1-yl)phenol

: 1594781-87-9
[1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl](4-methoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0.25 h / 20 °C / Inert atmosphere

1.2: 4.5 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / 1,4-dioxane / 20 °C / Inert atmosphere

With aluminum (III) chloride; water; sodium hydroxide; In 1,4-dioxane; 1,2-dichloro-ethane; 1.1: |Friedel-Crafts Acylation / 1.2: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmc.2014.02.016

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 1594781-87-9
[1-(3-fluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl](4-methoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 0.25 h / 20 °C / Inert atmosphere

1.2: 4.5 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / 1,4-dioxane / 20 °C / Inert atmosphere

With aluminum (III) chloride; water; sodium hydroxide; In 1,4-dioxane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2014.02.016