9-chloro-7-(2-fluorophenyl)-4a,5-dihydro-N,N-dimethyl-1H-<1,2,5>oxadiazino<5,4-a><1,4>benzodiazepine-4-carboxamide

Base Information

Chemical Name:9-chloro-7-(2-fluorophenyl)-4a,5-dihydro-N,N-dimethyl-1H-<1,2,5>oxadiazino<5,4-a><1,4>benzodiazepine-4-carboxamide
CAS No.:109774-36-9
Molecular Formula:C₂₀H₁₈ClFN₄O₂
Molecular Weight:400.84
Hs Code.:

Synonyms:9-chloro-7-(2-fluorophenyl)-4a,5-dihydro-N,N-dimethyl-1H-<1,2,5>oxadiazino<5,4-a><1,4>benzodiazepine-4-carboxamide

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Chemical Property of 9-chloro-7-(2-fluorophenyl)-4a,5-dihydro-N,N-dimethyl-1H-<1,2,5>oxadiazino<5,4-a><1,4>benzodiazepine-4-carboxamide

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Technology Process of 9-chloro-7-(2-fluorophenyl)-4a,5-dihydro-N,N-dimethyl-1H-<1,2,5>oxadiazino<5,4-a><1,4>benzodiazepine-4-carboxamide

There total 5 articles about 9-chloro-7-(2-fluorophenyl)-4a,5-dihydro-N,N-dimethyl-1H-<1,2,5>oxadiazino<5,4-a><1,4>benzodiazepine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 109774-31-4
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-alpha-(hydroxyimino)-N,N-dimethyl-1H-1,4-benzodiazepine-2-acetamide

: 109774-36-9
9-chloro-7-(2-fluorophenyl)-4a,5-dihydro-N,N-dimethyl-1H-<1,2,5>oxadiazino<5,4-a><1,4>benzodiazepine-4-carboxamide

Guidance literature:: With Trimethylacetic acid; In 1,2-dichloro-ethane; for 1.5h; Heating;
DOI:10.1002/jhet.5570230509

Reference yield:

: 109774-04-1
<7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-ylidene>N,N-dimethylacetamide

: 109774-36-9
9-chloro-7-(2-fluorophenyl)-4a,5-dihydro-N,N-dimethyl-1H-<1,2,5>oxadiazino<5,4-a><1,4>benzodiazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / sodium nitrite, acetic acid / 0.25 h / Ambient temperature

2: 50 percent / sodium borohydride, ethanol / 48 h / Ambient temperature

3: 96 percent / pivalic acid / 1,2-dichloro-ethane / 1.5 h / Heating

With sodium tetrahydroborate; ethanol; acetic acid; sodium nitrite; Trimethylacetic acid; In 1,2-dichloro-ethane;
DOI:10.1002/jhet.5570230509

Reference yield:

: 109774-13-2
7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-N,N-dimethyl-3H-1,4-benzodiazepine-2-acetamide

: 109774-36-9
9-chloro-7-(2-fluorophenyl)-4a,5-dihydro-N,N-dimethyl-1H-<1,2,5>oxadiazino<5,4-a><1,4>benzodiazepine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / sodium borohydride, ethanol / 48 h / Ambient temperature

2: 96 percent / pivalic acid / 1,2-dichloro-ethane / 1.5 h / Heating

With sodium tetrahydroborate; ethanol; Trimethylacetic acid; In 1,2-dichloro-ethane;
DOI:10.1002/jhet.5570230509