2-(tetrahydro-2H-pyran-2-yl)-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-indazol-4-amine

Base Information

Chemical Name:2-(tetrahydro-2H-pyran-2-yl)-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-indazol-4-amine
CAS No.:1198802-78-6
Molecular Formula:C₂₃H₂₇N₃O₃
Molecular Weight:393.486
Hs Code.:

Synonyms:2-(tetrahydro-2H-pyran-2-yl)-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-indazol-4-amine

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Chemical Property of 2-(tetrahydro-2H-pyran-2-yl)-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-indazol-4-amine

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Technology Process of 2-(tetrahydro-2H-pyran-2-yl)-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-indazol-4-amine

There total 4 articles about 2-(tetrahydro-2H-pyran-2-yl)-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-indazol-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198802-77-5
4-nitro-2-(tetrahydro-2H-pyran-2-yl)-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-indazole

: 1198802-78-6
2-(tetrahydro-2H-pyran-2-yl)-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-indazol-4-amine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 30 ℃; under 22502.3 Torr;
DOI:10.1021/acsmedchemlett.7b00296

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1198802-78-6
2-(tetrahydro-2H-pyran-2-yl)-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-indazol-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / 1.5 h / Reflux

2: sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / isopropyl alcohol; water / 0.17 h / 150 °C / Microwave irradiation

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 30 °C / 22502.3 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; In water; ethyl acetate; isopropyl alcohol;
DOI:10.1021/acsmedchemlett.7b00296

Reference yield:

: 885518-46-7
6-bromo-4-nitro-1H-indazole

: 1198802-78-6
2-(tetrahydro-2H-pyran-2-yl)-6-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-indazol-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / 1.5 h / Reflux

2: sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / isopropyl alcohol; water / 0.17 h / 150 °C / Microwave irradiation

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 30 °C / 22502.3 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; trifluoroacetic acid; In water; ethyl acetate; isopropyl alcohol;
DOI:10.1021/acsmedchemlett.7b00296