1-[(2R)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

Base Information

• Chemical Name: 1-[(2R)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide
• CAS No.: 1033221-35-0
• Molecular Formula: C₁₇H₁₉N₃O₃S
• Molecular Weight: 345.422

Synonyms:1-[(2R)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

Chemical Property of 1-[(2R)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

Chemical Property:

Purity/Quality:

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Technology Process of 1-[(2R)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

There total 3 articles about 1-[(2R)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(morpholin-2-ylmethyl)-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide hydrochloride (1033214-32-2) → 1-[(2S)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (1033221-38-3) + 1-[(2R)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (1033221-35-0)

Guidance literature:

In methanol; Resolution of racemate;

Reference yield:

1-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (1033224-60-0) → 1-[(2S)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (1033221-38-3) + 1-[(2R)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (1033221-35-0)

Guidance literature:

Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane; dichloromethane

3: chiralpak AS-H / Resolution of racemate

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1: Mitsunobu reaction;

DOI:10.1021/jm200733r

Reference yield:

1-(morpholin-2-ylmethyl)-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (1033221-32-7) → 1-[(2S)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (1033221-38-3) + 1-[(2R)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide (1033221-35-0)

Guidance literature:

With chiralpak AS-H; Resolution of racemate;

DOI:10.1021/jm200733r

upstream raw materials:

1-(morpholin-2-ylmethyl)-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide hydrochloride

1-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

1-(morpholin-2-ylmethyl)-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

Downstream raw materials:

1-((2R)-morpholin-2-ylmethyl)-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide hydrochloride

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