(E)-5-(4-fluorophenyl)-2-(2-phenylethynyl)-N-tosylpent-2-en-4-ynamide

Base Information

• Chemical Name: (E)-5-(4-fluorophenyl)-2-(2-phenylethynyl)-N-tosylpent-2-en-4-ynamide
• CAS No.: 1575710-13-2
• Molecular Formula: C₂₆H₁₈FNO₃S
• Molecular Weight: 443.498
• Mol file: 1575710-13-2.mol

Synonyms:(E)-5-(4-fluorophenyl)-2-(2-phenylethynyl)-N-tosylpent-2-en-4-ynamide

Chemical Property of (E)-5-(4-fluorophenyl)-2-(2-phenylethynyl)-N-tosylpent-2-en-4-ynamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-5-(4-fluorophenyl)-2-(2-phenylethynyl)-N-tosylpent-2-en-4-ynamide

There total 1 articles about (E)-5-(4-fluorophenyl)-2-(2-phenylethynyl)-N-tosylpent-2-en-4-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-toluenesulfonyl azide (941-55-9) + buta-1,3-diynylbenzene (5701-81-5) + 3-(4-fluorophenyl)-2-propynal (74929-23-0) → (E)-5-(4-fluorophenyl)-2-(2-phenylethynyl)-N-tosylpent-2-en-4-ynamide (1575710-13-2)

Guidance literature:

With copper(l) iodide; tetraethylammonium iodide; lithium hydroxide; In tetrahydrofuran; tert-butyl alcohol; at 10 ℃; for 6h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ol500574b

Reference yield: 81.0%

(E)-5-(4-fluorophenyl)-2-(2-phenylethynyl)-N-tosylpent-2-en-4-ynamide (1575710-13-2) → 6-(4-fluorophenyl)-2-phenylfuro[2,3-b]pyridine (1575710-95-0)

Guidance literature:

With palladium(II) acetylacetonate; In trifluoroacetic acid; at 60 ℃; for 10h; Inert atmosphere;

DOI:10.1021/ol500574b

Reference yield: 63.0%

(E)-5-(4-fluorophenyl)-2-(2-phenylethynyl)-N-tosylpent-2-en-4-ynamide (1575710-13-2) → 3,7-dibenzoyl-4,8-bis(4-fluorophenyl)naphthalene-2,6-dicarboxylic acid

Guidance literature:

(E)-5-(4-fluorophenyl)-2-(2-phenylethynyl)-N-tosylpent-2-en-4-ynamide; With oxygen; palladium diacetate; sodium iodide; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 12.5h; under 760.051 Torr; Molecular sieve;

With sodium hydroxide; In dimethyl sulfoxide; at 120 ℃; for 8h;

DOI:10.1002/chem.201504085

upstream raw materials:

4-toluenesulfonyl azide

buta-1,3-diynylbenzene

3-(4-fluorophenyl)-2-propynal

Downstream raw materials:

6-(4-fluorophenyl)-2-phenylfuro[2,3-b]pyridine

3,5-diallyl-6-(4-fluorophenyl)-2-phenylfuro[2,3-b]pyridine