4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzamide

Base Information

Chemical Name:4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzamide
CAS No.:1407832-56-7
Molecular Formula:C₂₄H₂₃N₇O
Molecular Weight:425.493
Hs Code.:

Synonyms:4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzamide

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Chemical Property of 4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzamide

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Technology Process of 4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzamide

There total 7 articles about 4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.8%

: 1407834-68-7
4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzonitrile

: 1407832-56-7
4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzamide

Guidance literature:: With water; triphenylphosphine; palladium diacetate; In ethanol; at 60 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 1407833-48-0
methyl 3-(5-bromo-2-nitrophenylamino)-2-methylpropanoate

: 1407832-56-7
4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium chloride; iron / ethanol; water / 2 h / 60 °C

2: sodium / methanol / 0 - 20 °C

3: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

4: butan-1-ol / 12 h / 130 °C

5: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 180 °C / 12901.3 Torr / Microwave irradiation

6: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 0.5 h / 100 °C / 12901.3 Torr / Microwave irradiation

7: triphenylphosphine; water / palladium diacetate / ethanol / 0.5 h / 60 °C / Inert atmosphere

With Lawessons reagent; water; sodium; iron; potassium carbonate; ammonium chloride; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1407833-52-6
methyl 3-(2-amino-5-bromophenylamino)-2-methylpropanoate

: 1407832-56-7
4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium / methanol / 0 - 20 °C

2: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

3: butan-1-ol / 12 h / 130 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 180 °C / 12901.3 Torr / Microwave irradiation

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 0.5 h / 100 °C / 12901.3 Torr / Microwave irradiation

6: triphenylphosphine; water / palladium diacetate / ethanol / 0.5 h / 60 °C / Inert atmosphere

With Lawessons reagent; water; sodium; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;