4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzonitrile

Base Information

Chemical Name:4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzonitrile
CAS No.:1407834-68-7
Molecular Formula:C₂₄H₂₁N₇
Molecular Weight:407.478
Hs Code.:

Synonyms:4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzonitrile

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Chemical Property of 4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzonitrile

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Technology Process of 4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzonitrile

There total 6 articles about 4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.4%

: 827614-64-2
2-aminopyridine-5-boronic acid pinacol ester

: 1407834-20-1
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-1,4-dimethyl-8-bromo-6-(4-cyano-phenyl)

: 1407834-68-7
4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzonitrile

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; at 100 ℃; for 0.5h; under 12901.3 Torr; Microwave irradiation;

Reference yield:

: 1407833-48-0
methyl 3-(5-bromo-2-nitrophenylamino)-2-methylpropanoate

: 1407834-68-7
4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium chloride; iron / ethanol; water / 2 h / 60 °C

2: sodium / methanol / 0 - 20 °C

3: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

4: butan-1-ol / 12 h / 130 °C

5: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 180 °C / 12901.3 Torr / Microwave irradiation

6: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 0.5 h / 100 °C / 12901.3 Torr / Microwave irradiation

With Lawessons reagent; sodium; iron; potassium carbonate; ammonium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 1407833-52-6
methyl 3-(2-amino-5-bromophenylamino)-2-methylpropanoate

: 1407834-68-7
4-(8-(6-aminopyridin-3-yl)-1,4-dimethyl-4H-benzo[b][1,2,4]triazolo[4,3-d][1,4]diazepin-6(5H)-yl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: sodium / methanol / 0 - 20 °C

2: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

3: butan-1-ol / 12 h / 130 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 180 °C / 12901.3 Torr / Microwave irradiation

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; tetrahydrofuran / 0.5 h / 100 °C / 12901.3 Torr / Microwave irradiation

With Lawessons reagent; sodium; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; butan-1-ol;