N-[6-(3-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

Base Information

Chemical Name:N-[6-(3-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide
CAS No.:1092394-58-5
Molecular Formula:C₁₇H₁₄N₄O₄
Molecular Weight:338.323
Hs Code.:

Synonyms:N-[6-(3-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

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Chemical Property of N-[6-(3-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

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Technology Process of N-[6-(3-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

There total 9 articles about N-[6-(3-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1092394-56-3
6-(3-nitrophenoxy)imidazo[1,2-a]pyridin-2-amine

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1092394-58-5
N-[6-(3-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: 6-(3-nitrophenoxy)imidazo[1,2-a]pyridin-2-amine; cyclopropanecarboxylic acid chloride; With pyridine; at 0 - 20 ℃; for 3h;

With methanol; water; sodium carbonate; at 60 ℃; for 2h;

Reference yield:

: 827028-99-9
5-(3-nitrophenoxy)pyridine-2-carboxylic acid

: 1092394-58-5
N-[6-(3-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: diphenyl phosphoryl azide; triethylamine / 18 h / 20 °C / Heating / reflux

2.1: trifluoroacetic acid / 1 h / 20 °C

3.1: pyridine / 2 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

4.2: 15 h / 20 °C

5.1: trifluoroacetic anhydride / dichloromethane / 5 h / 20 °C

5.2: 15 h / 20 °C

6.1: pyridine / 3 h / 0 - 20 °C

6.2: 2 h / 60 °C

With pyridine; diphenyl phosphoryl azide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 228401-34-1
3-(5-methyl-3-pyridinyloxy)-1-nitrobenzene

: 1092394-58-5
N-[6-(3-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine; potassium permanganate / water / 12 h / 85 °C

2.1: diphenyl phosphoryl azide; triethylamine / 18 h / 20 °C / Heating / reflux

3.1: trifluoroacetic acid / 1 h / 20 °C

4.1: pyridine / 2 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

5.2: 15 h / 20 °C

6.1: trifluoroacetic anhydride / dichloromethane / 5 h / 20 °C

6.2: 15 h / 20 °C

7.1: pyridine / 3 h / 0 - 20 °C

7.2: 2 h / 60 °C

With pyridine; potassium permanganate; diphenyl phosphoryl azide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; In dichloromethane; water; N,N-dimethyl-formamide;