Technology Process of N-[6-(3-aminophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide
There total 10 articles about N-[6-(3-aminophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-[6-(3-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide;
With
hydrogen;
palladium on activated charcoal;
In
methanol;
at 20 ℃;
for 4h;
With
ammonium chloride; zinc;
In
methanol;
for 2h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 22 h / 90 - 140 °C
2.1: pyridine; potassium permanganate / water / 12 h / 85 °C
3.1: diphenyl phosphoryl azide; triethylamine / 18 h / 20 °C / Heating / reflux
4.1: trifluoroacetic acid / 1 h / 20 °C
5.1: pyridine / 2 h / 80 °C
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
6.2: 15 h / 20 °C
7.1: trifluoroacetic anhydride / dichloromethane / 5 h / 20 °C
7.2: 15 h / 20 °C
8.1: pyridine / 3 h / 0 - 20 °C
8.2: 2 h / 60 °C
9.1: hydrogen / palladium on activated charcoal / methanol / 4 h / 20 °C
9.2: 2 h / Heating / reflux
With
pyridine; potassium permanganate; diphenyl phosphoryl azide; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride;
palladium on activated charcoal;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: pyridine; potassium permanganate / water / 12 h / 85 °C
2.1: diphenyl phosphoryl azide; triethylamine / 18 h / 20 °C / Heating / reflux
3.1: trifluoroacetic acid / 1 h / 20 °C
4.1: pyridine / 2 h / 80 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C
5.2: 15 h / 20 °C
6.1: trifluoroacetic anhydride / dichloromethane / 5 h / 20 °C
6.2: 15 h / 20 °C
7.1: pyridine / 3 h / 0 - 20 °C
7.2: 2 h / 60 °C
8.1: hydrogen / palladium on activated charcoal / methanol / 4 h / 20 °C
8.2: 2 h / Heating / reflux
With
pyridine; potassium permanganate; diphenyl phosphoryl azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride;
palladium on activated charcoal;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
![N-[6-(3-nitrophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide](/Databaselist/images/loading.webp)
