(-)-2,5-diketo-6-(R)-allyl-4-(methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

Base Information

• Chemical Name: (-)-2,5-diketo-6-(R)-allyl-4-(methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane
• CAS No.: 116005-52-8
• Molecular Formula: C₁₈H₂₂N₂O₃
• Molecular Weight: 314.384
• Mol file: 116005-52-8.mol

Synonyms:(-)-2,5-diketo-6-(R)-allyl-4-(methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

Chemical Property of (-)-2,5-diketo-6-(R)-allyl-4-(methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-2,5-diketo-6-(R)-allyl-4-(methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

There total 4 articles about (-)-2,5-diketo-6-(R)-allyl-4-(methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,5R)-5-allyl-2-tert-butyl-1-aza-3-oxabicyclo<3.3.0>octan-4-one (81286-83-1) → (-)-2,5-diketo-6-(R)-allyl-4-(methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane (116005-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / tetrahydrofuran

2: 1.) K₂CO₃, 2.) NaOH / 1.) CH₂Cl₂, 2.) CH₂Cl₂

With sodium hydroxide; potassium carbonate; In tetrahydrofuran;

DOI:10.1021/ja00225a069

Reference yield:

p-methoxybenzylamine lithium → (-)-2,5-diketo-6-(R)-allyl-4-(methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane (116005-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / tetrahydrofuran

2: 1.) K₂CO₃, 2.) NaOH / 1.) CH₂Cl₂, 2.) CH₂Cl₂

With sodium hydroxide; potassium carbonate; In tetrahydrofuran;

DOI:10.1021/ja00225a069

Reference yield:

(-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine (116005-51-7) + 2-Bromoacetyl bromide (598-21-0) → (-)-2,5-diketo-6-(R)-allyl-4-(methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane (116005-52-8)

Guidance literature:

With sodium hydroxide; potassium carbonate; Yield given. Multistep reaction; 1.) methylene chloride, 0 deg C, 1 h, 2.) 8 h;

upstream raw materials:

(-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine

2-Bromoacetyl bromide

(2R,5R)-5-allyl-2-tert-butyl-1-aza-3-oxabicyclo<3.3.0>octan-4-one

4-methoxy-benzylamine

Downstream raw materials:

6-<(2E)-4-hydroxy-3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

(+)-6-(R)-<(2E)-4-<(tert-butyldimethylsilyl)oxy>3-methylbut-2-enyl>-3-(R)(carbometoxy)-2,5-diketo-3-<(3-indolyl)methyl>-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

6-<(2E)-4-<(tert-butyldimethylsilyl)oxy>but-2-enyl>-3-(carbomethoxy)-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

3-[(3R,8aR)-8a-((E)-4-Chloro-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester