4-(1-(5-(6-((2-methoxyethyl)(methyl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile trifluoroacetate

Base Information

Chemical Name:4-(1-(5-(6-((2-methoxyethyl)(methyl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile trifluoroacetate
CAS No.:1399176-01-2
Molecular Formula:C₂HF₃O₂*C₃₁H₃₄N₆O₂
Molecular Weight:636.674
Hs Code.:

Synonyms:4-(1-(5-(6-((2-methoxyethyl)(methyl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile trifluoroacetate

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Chemical Property of 4-(1-(5-(6-((2-methoxyethyl)(methyl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile trifluoroacetate

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Technology Process of 4-(1-(5-(6-((2-methoxyethyl)(methyl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile trifluoroacetate

There total 11 articles about 4-(1-(5-(6-((2-methoxyethyl)(methyl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1399181-26-0
N²-(2-methoxyethyl)-N²-methylpyridine-2,4,5-triamine

: 1399181-27-1
4-(1-(5-formyl-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile

: 76-05-1
trifluoroacetic acid

: 1399176-01-2
4-(1-(5-(6-((2-methoxyethyl)(methyl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile trifluoroacetate

Guidance literature:: N²-(2-methoxyethyl)-N²-methylpyridine-2,4,5-triamine; 4-(1-(5-formyl-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile; With ammonium acetate; In ethanol; at 70 ℃;

trifluoroacetic acid; In water; ethyl acetate;
DOI:10.1021/ml300335r

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 4-(1-(3-methyl-5-(6-(pyrrolidin-1-yl)-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl)piperidin-4-yl)benzonitrile trifluoroacetate

: 1399176-12-5
4-(1-(4-methyl-3-(6-(pyrrolidin-1-yl)-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl)piperidin-4-yl)benzonitrile

: 1415387-38-0
C₃₀H₃₀N₆O

: 1399176-26-1
5-(4-(4-cyanophenyl)piperidine-1-carbonyl)-2-methyl-N-(6-(pyrrolidin-1-yl)pyridin-3-yl)benzamide

: 1399176-16-9
4-(1-(2-methyl-5-(6-(pyrrolidin-1-yl)-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl)piperidin-4-yl)benzonitrile

: 1399176-01-2
4-(1-(5-(6-((2-methoxyethyl)(methyl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

3.1: trichlorophosphate / pyridine / 20 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

5.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

7.1: ammonium acetate / ethanol / 70 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; palladium 10% on activated carbon; ammonium acetate; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; pyridine; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml300335r

Reference yield:

: 742081-03-4
5-iodo-2,4-dimethylbenzoic acid

: 1399176-01-2
4-(1-(5-(6-((2-methoxyethyl)(methyl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)-2,4-dimethylbenzoyl)piperidin-4-yl)benzonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

3.1: ammonium acetate / ethanol / 70 °C

3.2: silica gel

With n-butyllithium; ammonium acetate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ml300335r