1399176-16-9

Upstream product

• 162997-33-3 tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate 
• 460365-08-6 4-(4-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 871112-38-8 tert-butyl 4-(4-cyanophenyl)-4-hydroxypiperidine-1-carboxylate 
• 162997-34-4 4-(piperidin-4-yl)benzonitrile hydrochloride 
• 105650-34-8 5-formyl-2-methylbenzoic acid 
• 79669-49-1 5-bromo-2-methylbenzoic acid 
• 163209-96-9 tert-butyl 4-(4-bromophenyl)-4-hydroxypiperidine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 589-87-7 1,4-bromoiodobenzene 
• 1399181-29-3 6-(pyrrolidin-1-yl)pyridine-3,4-diamine 
• 1399181-28-2 5-nitro-2-(pyrrolidin-1-yl)pyridin-4-amine 
• 2604-39-9 4-amino-2-chloro-5-nitropyridine 

Relevant academic research and scientific papers

Imidazopyridine-based fatty acid synthase inhibitors that show anti-HCV activity and in vivo target modulation

Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochemical activities. The most potent analogue (compound 19) also inhibits rat FASN and inhibits de novo palmitate synthesis in vitro (cell-based) as well as in vivo.

HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS

Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are