2-benzyl-5-oxacyclooctanone

Base Information

Chemical Name:2-benzyl-5-oxacyclooctanone
CAS No.:141401-11-8
Molecular Formula:C₁₄H₁₈O₂
Molecular Weight:218.296
Hs Code.:

Synonyms:2-benzyl-5-oxacyclooctanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-benzyl-5-oxacyclooctanone

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Technology Process of 2-benzyl-5-oxacyclooctanone

There total 6 articles about 2-benzyl-5-oxacyclooctanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.7%

: 141401-50-5
4-Benzyl-6-(2-methylamino-benzenesulfinyl)-oxocan-5-one

: 141401-11-8
2-benzyl-5-oxacyclooctanone

Guidance literature:: nickel; In acetone; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.40.617

Reference yield:

: 100-39-0
benzyl bromide

: 141401-11-8
2-benzyl-5-oxacyclooctanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, a) -78 deg C, 30 min, b) 0 deg C, 1 h

2: 96.4 percent / NaIO₄ / methanol; H₂O / 20 h / Ambient temperature

3: LDA / hexane; tetrahydrofuran / a) -60 deg C, 30 min, b) 0 deg C, 30 min

4: 92.7 percent / Raney Ni / acetone / 0.5 h / Ambient temperature

With sodium periodate; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; hexane; water; acetone;
DOI:10.1248/cpb.40.617

Reference yield:

: 141401-38-9
3-methyl-8-oxa-12-thia-3-aza-1,2-benzocyclododecan-4-one

: 141401-11-8
2-benzyl-5-oxacyclooctanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, a) -78 deg C, 30 min, b) 0 deg C, 1 h

2: 96.4 percent / NaIO₄ / methanol; H₂O / 20 h / Ambient temperature

3: LDA / hexane; tetrahydrofuran / a) -60 deg C, 30 min, b) 0 deg C, 30 min

4: 92.7 percent / Raney Ni / acetone / 0.5 h / Ambient temperature

With sodium periodate; lithium diisopropyl amide; nickel; In tetrahydrofuran; methanol; hexane; water; acetone;
DOI:10.1248/cpb.40.617