1,1-dimethylethyl [3-({4-[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]carbamate

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Chemical Name:1,1-dimethylethyl [3-({4-[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]carbamate
CAS No.:1208170-21-1
Molecular Formula:C₂₂H₂₈N₆O₃
Molecular Weight:424.503
Hs Code.:

Synonyms:1,1-dimethylethyl [3-({4-[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]carbamate

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Chemical Property of 1,1-dimethylethyl [3-({4-[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]carbamate

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Technology Process of 1,1-dimethylethyl [3-({4-[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]carbamate

There total 10 articles about 1,1-dimethylethyl [3-({4-[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1208170-04-0
4-[(3-methylphenyl)amino]-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one

: 75178-96-0
N-Boc-1,3-diaminopropane

: 1208170-21-1
1,1-dimethylethyl [3-({4-[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]carbamate

Guidance literature:: 4-[(3-methylphenyl)amino]-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one; With 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide;

N-Boc-1,3-diaminopropane; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 1208170-17-5
4-chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile

: 1208170-21-1
1,1-dimethylethyl [3-({4-[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 75 °C

2.1: N,N-dimethyl-formamide / 1.5 h / 110 °C

3.1: acetic acid; hydrogen bromide / 0.33 h / 20 °C

4.1: acetic acid; hydrogenchloride; water / 1.5 h / 80 °C

5.1: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide

5.2: 1 h

With hydrogenchloride; water; hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2019.151312

Reference yield:

: 5417-82-3
(1-ethoxyethylidene)malononitrile

: 1208170-21-1
1,1-dimethylethyl [3-({4-[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate / methanol / 0 - 20 °C

2.1: magnesium sulfate; copper dichloride; tert.-butylnitrite / acetonitrile / 3 h / 80 °C

3.1: N,N-dimethyl-formamide / 1.5 h / 20 °C

4.1: N,N-dimethyl-formamide / 1 h / 110 °C

5.1: acetic acid; hydrogen bromide; water / 1.5 h / 83 °C

6.1: hydrogenchloride / isopropyl alcohol; water / 24 h / Reflux

7.1: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide

7.2: 1 h

With hydrogenchloride; tert.-butylnitrite; water; hydrogen bromide; sodium methylate; magnesium sulfate; acetic acid; 3-chloro-benzenecarboperoxoic acid; copper dichloride; In methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.tetlet.2019.151312