[(3-Bromo-phenyl)-(diethoxy-thiophosphorylamino)-methyl]-phosphonic acid diphenyl ester

Base Information

• Chemical Name: [(3-Bromo-phenyl)-(diethoxy-thiophosphorylamino)-methyl]-phosphonic acid diphenyl ester
• CAS No.: 110814-43-2
• Molecular Formula: C₂₃H₂₆BrNO₅P₂S
• Molecular Weight: 570.381
• Mol file: 110814-43-2.mol

Synonyms:[(3-Bromo-phenyl)-(diethoxy-thiophosphorylamino)-methyl]-phosphonic acid diphenyl ester

Chemical Property of [(3-Bromo-phenyl)-(diethoxy-thiophosphorylamino)-methyl]-phosphonic acid diphenyl ester

Chemical Property:

Purity/Quality:

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Technology Process of [(3-Bromo-phenyl)-(diethoxy-thiophosphorylamino)-methyl]-phosphonic acid diphenyl ester

There total 1 articles about [(3-Bromo-phenyl)-(diethoxy-thiophosphorylamino)-methyl]-phosphonic acid diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triphenyl phosphite (101-02-0) + m-bromobenzoic aldehyde (3132-99-8) + O,O-diethyl phosphoramidothioate (17321-48-1) → [(3-Bromo-phenyl)-(diethoxy-thiophosphorylamino)-methyl]-phosphonic acid diphenyl ester (110814-43-2)

Guidance literature:

With boron trifluoride diethyl etherate; Yield given. Multistep reaction; 1.) DME, room temp., 20 min; 80 deg C, 15 min, 2.) reflux, 5 h;

DOI:10.1055/s-1986-31790

Reference yield: 90.0%

[(3-Bromo-phenyl)-(diethoxy-thiophosphorylamino)-methyl]-phosphonic acid diphenyl ester (110814-43-2) → [Amino-(3-bromo-phenyl)-methyl]-phosphonic acid diphenyl ester; hydrobromide (106787-33-1)

Guidance literature:

With hydrogen bromide; In acetic acid; for 0.5h; Ambient temperature;

DOI:10.1055/s-1986-31790

upstream raw materials:

triphenyl phosphite

m-bromobenzoic aldehyde

O,O-diethyl phosphoramidothioate

Downstream raw materials:

[Amino-(3-bromo-phenyl)-methyl]-phosphonic acid diphenyl ester; hydrobromide